Table 6.
Distribution of SERT genotypes by IBS subtype
| Polymorphism | Genotype | Constipation-predominant total n = 42 n (%) |
Diarrhea-predominant total n = 98 n (%) |
Alternators total n = 36 n (%) |
Normal stool total n = 10 n (%) |
|---|---|---|---|---|---|
| 5-HTTLPR | s/s | 8 (19) | 18 (18) | 7 (19) | 2 (20) |
| s/l | 19 (45) | 41 (42) | 15 (42) | 6 (60) | |
| l/l | 15 (36) | 39 (40) | 13 (36) | 2 (20) | |
| l/xl | 0 | 0 | 1 (3) | 0 | |
| STin2 VNTR | 10/10 | 2 (5) | 16 (16) | 9 (25) | 0 |
| 10/12 | 20 (48) | 39 (40) | 13 (36) | 3 (30) | |
| 12/12 | 19 (45) | 35 (36) | 14 (39) | 6 (60) | |
| 9/12 | 1 (2) | 6 (6) | 0 | 1 (10) | |
| 9/10 | 0 | 2 (2) | 0 | 0 | |
| rs25531 | A/A | 36 (86) | 74 (76) | 29 (81) | 6 (60) |
| A/G | 6 (14) | 24 (24) | 7 (19) | 4 (40) |
Note: Shown are the comparisons between IBS subjects with different bowel patterns. Genotype distributions did not differ significantly by bowel pattern for any of the three polymorphisms shown (Fisher's exact test)