TABLE 1.

Genotype and Allele Frequencies of the CASP8 and CASP10 SNPsin Non-Hispanic White Patients with CM and Control Subjects and Their Associations with Risk of CM

	Cases (n = 805)		Controlsa (n = 835)			Crude OR (95% CI)	Adjusted OR (95% CI)c
Variable	No.	%	No.	%	P valueb
CASP8 D302H (rs1045485:G>C)					0.088d
DD	629	78.1	615	73.6		1.00	1.00
DH	168	20.9	207	24.8		0.79 (0.63-1.00)	0.70 (0.50-0.98)
HH	8	1.0	13	1.6		0.60 (0.25-1.46)	1.00 (0.27-3.74)
DH+HH	176	21.9	220	26.4	0.034e	0.78 (0.62-0.98)	0.71 (0.51-0.99)
H allele frequency	0.114		0.140		0.029f
CASP8 -652 6N					0.042d
ins/ins	243	30.2	207	24.8		1.00
ins/del	385	47.8	440	52.7		0.75 (0.60-0.95)	0.74 (0.57-0.97)
del/del	177	22.0	188	22.5		0.81 (0.61-1.06)	0.78 (0.56-1.07)
ins/del+del/del	562	69.8	628	75.2	0.014e	0.76 (0.61-0.95)	0.75 (0.58-0.97)
del allele frequency	0.459		0.489		0.092f
CASP10 I522L (rs13006529:A>T)					0.439d
II	206	25.6	239	28.6		1.00	1.00
IL	418	51.9	415	49.7		1.17 (0.93-1.47)	1.15 (0.88-1.50)
LL	181	22.5	181	21.7		1.16 (0.88-1.53)	1.09 (0.79-1.50)
IL+LL	599	74.4	596	71.4	0.206e	1.17 (0.94-1.45)	1.13 (0.88-1.46)
L allele frequency	0.484		0.465		0.292f

^aThe observed genotype frequency in the controls was in agreement with the Hardy-Weinberg equilibrium (CASP8 D302H: χ² = 0.880, P = 0.348; CASP8 -652 6N: χ² = 2.474, P = 0.116; CASP10 I522L: χ² = 0.001, P = 0.973).

^bTwo-sided chi-square test for either genotype distribution or allele frequency.

^cORs were adjusted for age, sex, skin color, eye color, hair color, tanning ability, lifetime number of sunburns with blistering, freckling in the sun as a child, presence of moles or dysplastic nevi, and family history of cancer in a logistic regression model.

^dDistribution of three genotypes.

^eDistribution of combined genotypes.

^fAllele distribution.