TABLE 2.
Stratification Analysis of Associations between the Genotypes of the CASP8 D302H, CASP8 -652 6N, and CASP10 I522L SNPs and CM Riska
| CASP8 D302H (cases/controls) | CASP8 -652 6N (cases/controls) | CASP10 1522L (cases/controls) | |||||||
|---|---|---|---|---|---|---|---|---|---|
| Variable | DD | DH+HH | Adjusted ORb (95% CI) |
ins/del | ins/ins +del/del |
Adjusted ORb (95% CI) |
II | IL+LL | Adjusted ORb (95% CI) |
| Age | |||||||||
| ≤ 50 | 240/237 | 84/68 | 1.08 (0.70-1.67) | 96/84 | 228/221 | 0.88 (0.59-1.32) | 79/98 | 245/207 | 1.49 (0.99-2.26) |
| > 50 | 388/378 | 93/152 | 0.59 (0.42-0.83) | 147/123 | 334/407 | 0.67 (0.48-0.92)x | 129/141 | 352/389 | 0.96 (0.69-1.32) |
| Interaction P value | 0.019 | 0.320 | 0.117 | ||||||
| Sex | |||||||||
| Male | 396/417 | 112/144 | 0.76 (0.54-1.06) | 140/131 | 368/430 | 0.78 (0.56-1.09) | 120/164 | 388/397 | 1.42 (1.02-1.97) |
| Female | 232/198 | 65/76 | 0.66 (0.42-1.02) | 103/76 | 194/198 | 0.67 (0.45-1.01) | 88/75 | 209/199 | 0.88 (0.61-1.26) |
| Interaction P value | 0.710 | 0.561 | 0.025 | ||||||
| Hair color | |||||||||
| Black or brown | 259/251 | 68/93 | 0.69 (0.50-0.93) | 97/84 | 230/260 | 0.76 (0.57-1.02) | 77/102 | 250/242 | 1.12 (0.84-1.51) |
| Blonde or red | 313/277 | 92/97 | 0.89 (0.53-1.49) | 119/88 | 286/286 | 0.62 (0.36-1.06) | 107/99 | 298/275 | 1.01 (0.60-1.69) |
| Interaction P value | 0.391 | 0.828 | 0.950 | ||||||
| Eye color | |||||||||
| Other | 331/391 | 94/139 | 0.74 (0.54-1.03) | 129/132 | 296/398 | 0.74 (0.57-0.95) | 101/152 | 324/378 | 1.30 (0.95-1.78) |
| Blue | 240/135 | 66/50 | 0.69 (0.44-1.10) | 86/39 | 20/146 | 2.46 (0.24-24.8) | 82/48 | 224/137 | 0.86 (0.55-1.35) |
| Interaction P value | 0.868 | 0.592 | 0.153 | ||||||
| Skin color | |||||||||
| Dark or brown | 384/425 | 102/152 | 0.68 (0.46-1.00) | 148/141 | 338/436 | 0.83 (0.57-1.19) | 123/160 | 363/417 | 1.42 (1.02-1.97) |
| Fair | 188/99 | 58/37 | 0.82(0.56-1.19) | 68/29 | 178/107 | 0.64 (0.44-0.92) | 61/38 | 185/98 | 0.88 (0.61-1.26) |
| Interaction P value | 0.483 | 0.366 | 0.053 | ||||||
| Tanning ability | |||||||||
| Good (high) | 160/231 | 35/94 | 0.66 (0.49-0.93) | 56/84 | 139/241 | 0.88 (0.64-1.22) | 50/96 | 145/229 | 1.44 (1.04-1.99) |
| Poor (low) | 410/296 | 125/94 | 0.94 (0.61-1.46) | 159/187 | 376/303 | 0.54 (0.35-0.84) | 133/103 | 402/287 | 0.74 (0.48-1.14) |
| Interaction P value | 0.270 | 0.117 | 0.021 | ||||||
| Lifetime sunburns with blistering | |||||||||
| None | 271/306 | 66/112 | 0.61 (0.38-0.97) | 90/99 | 247/319 | 0.88 (0.57-1.35) | 76/125 | 261/293 | 1.35 (0.87-2.08) |
| ≥ 1 | 297/220 | 94/77 | 0.90 (0.65-1.25) | 125/71 | 266/226 | 0.69 (0.50-0.95) | 108/75 | 283/222 | 1.08 (0.78-1.48) |
| Interaction P value | 0.056 | 0.320 | 0.556 | ||||||
| Freckling in the sun as a child | |||||||||
| No | 357/323 | 92/117 | 0.65 (0.45-0.94) | 127/116 | 322/324 | 0.79 (0.55-1.12) | 102/137 | 347/303 | 1.40 (0.98-1.99) |
| Yes | 215/204 | 68/72 | 0.85 (0.58-1.24) | 89/56 | 194/220 | 0.71 (0.49-1.02) | 82/64 | 201/212 | 0.88 (0.61-1.29) |
| Interaction P value | 0.378 | 0.485 | 0.066 | ||||||
| Moles | |||||||||
| No | 137/217 | 36/71 | 0.85 (0.53-.138) | 51/64 | 122/224 | 0.67 (0.42-1.07) | 48/75 | 125/213 | 0.84 (0.53-1.33) |
| Yes | 491/398 | 141/149 | 0.69 (0.50-0.95) | 192/143 | 440/404 | 0.78 (0.58-1.06) | 160/164 | 472/383 | 1.30 (0.96-1.76) |
| Interaction P value | 0.461 | 0.763 | 0.146 | ||||||
| Dysplastic nevi | |||||||||
| No | 579/612 | 160/214 | 0.77 (0.59-1.00) | 227/204 | 512/622 | 0.78 (0.58-1.07) | 196/236 | 543/590 | 1.12 (0.87-1.44) |
| Yes | 49/3 | 17/6 | 0.30 (0.03-2.94) | 16/3 | 50/6 | 0.63 (0.40-1.00) | 12/3 | 54/6 | 2.85 (0.22-37.4) |
| Interaction P value | 0.060 | 0.404 | 0.498 | ||||||
| First-degree relatives with any cancer | |||||||||
| No | 262/315 | 82/112 | 0.75 (0.50-1.14) | 97/104 | 247/323 | 0.76 (0.50-1.14) | 93/119 | 251/308 | 0.93 (0.62-1.39) |
| Yes | 366/300 | 95/108 | 0.71 (0.50-1.00) | 146/103 | 315/305 | 0.76 (0.58-1.04) | 115/120 | 346/288 | 1.31 (0.94-1.81) |
| Interaction P value | 0.813 | 0.962 | 0.198 | ||||||
a
The numbers of subjects in some of the strata were less than the total number of subjects because some subjects did not provide information.
b
ORs were adjusted for age, sex, skin color, eye color, hair color, tanning ability, lifetime number of sunburns with blistering, freckling in the sun as a child, presence of moles and dysplastic nevi, and family history of cancer in a multivariate logistic regression model.