. Author manuscript; available in PMC: 2010 Sep 13.

Published in final edited form as: Hum Mutat. 2008 Dec;29(12):1443–1451. doi: 10.1002/humu.20803

TABLE 5.

FPRP Values for Associations Between CM Risk and Frequencies of Genotypes and Haplotypes of CASP8 D302H (rs1045485:G>C), CASP8 -652 6N (rs3834129:-/CTTACT), and CASP10 I522L (rs13006529:A>T)

			Statistical	Prior probability
Genotype/ haplotype	OR^a (95% CI)	P value^b	power^c	0.2500	0.1000	0.0100	0.0010	0.0001
CASP8 D302H DH + HH versus DD	0.78 (0.62-0.98)	0.0340	0.900	0.10	0.25	0.79	0.97	1.00
CASP8 -652 6N Ins/del+del/del vs. Ins/ins	0.76 (0.61-0.95)	0.0140	0.890	0.04	0.12	0.61	0.94	0.99
D-del-I versus D-ins-I	0.58 (0.44-0.78)	< 0.0001	0.106	< 0.01	< 0.01	0.04	0.29	0.80

The unadjusted OR reported in Tables 2 and 3.

The omnibus chi-square test of the genotype and haplotype frequency distributions reported in Tables 2 and 3.

Calculated using study subjects to detect an OR of 1.5 or 0.67 with the common genotype or haplotype used as the reference.