Table 13.

Change in Optical Coherence Tomography Retinal Volume from Baseline to 1 Year^*

Change in OCT Retinal Volume†	Sham + Prompt Laser N = 189	Ranibizumab + Prompt Laser N = 117	Ranibizumab + Deferred Laser N = 132	Triamcinolone + Prompt Laser N = 121
Total volume (mm3) at 1 year
Mean±SD	8.1±1.4	7.3±1.0	7.4±1.2	7.5±1.3
Median (25th, 75th percentile)	7.9 (7.2, 8.7)	7.0 (6.6, 7.8)	7.1 (6.6, 7.8)	7.2 (6.7, 7.9)
Change in volume (mm3) from baseline
Mean±SD	−1.0±1.4	−1.4±1.4	−1.5±1.5	−1.4±1.6
Median (25th, 75th percentile)	−0.6 (−1.7, −0.1)	−1.1 (−2.1, −0.6)	−1.1 (−2.1, −0.4)	−1.2 (−2.2, −0.6)
Difference in mean change from sham+prompt laser (95% CI) [P Value]‡		−0.73 (−1.01, −0.44) [P<0.001]	−0.68 (−0.96, −0.41) [P<0.001]	−0.62 (−0.91, −0.34) [P<0.001]

OCT = optical coherence tomography; SD = standard deviation; CI = confidence interval.

^*Visits occurring between 308 and 420 days (between 44 and 60 weeks) from randomization were included as 1 year visits. When more than 1 visit occurred in this window, data from the visit closest to the 1-year target date were used.

^†Missing (or ungradeable) data as follows for the sham+prompt laser, ranibizumab+prompt laser, ranibizumab+deferred laser, and triamcinolone+prompt laser groups, respectively: 85, 54, 46, 55.

^‡Analysis of covariance adjusted for baseline OCT retinal volume, OCT retinal thickness and visual acuity and correlation between 2 study eyes. Confidence intervals are adjusted for multiple comparisons.