Table 17.

Cardiovascular Events According to Antiplatelet Trialists’ Collaboration^* through 1 and 2 Years

	Through 1 Yr			Through 2 Yrs
	Sham†N‡=130	Ranibizumab N‡=375	Triamcinolone N‡=186	Sham†N‡=130	Ranibizumab N‡=375	Triamcinolone N‡=186
Nonfatal myocardial infarction, No. (%)	3 (2%)	1 (<1%)	2 (1%)	4 (3%)	5 (1%)	5 (3%)
Nonfatal cerebrovascular accident—ischemic or hemorrhagic (or unknown), No. (%)	5 (4%)	3 (1%)	1 (1%)	8 (6%)	6 (2%)	3 (2%)
Vascular death (from any potential vascular or unknown cause§), No. (%)	4 (3%)	7 (2%)	2 (1%)	6 (5%)	8 (2%)	4 (2%)
Any ATC cardiovascular event, No. (%)	10 (8%)	11 (3%)	5 (3%)	15 (12%)	19 (5%)	12 (6%)

ATC = Antiplatelet Trialists’ Collaboration.

^*Collaborative overview of randomised trials of antiplatelet therapy—I: Prevention of death, myocardial infarction, and stroke by prolonged antiplatelet therapy in various categories of patients. Antiplatelet Trialists’ Collaboration. BMJ 1994;308:81-106.

^†One participant had a nonfatal myocardial infarction and a nonfatal stroke and 1 participant had a nonfatal myocardial infarction and a subsequent vascular death through 1 year; an additional participant had a nonfatal stroke and a subsequent vascular death through 2 years. Multiple events are counted once in the any ATC cardiovascular event row.

^‡N = number of study participants. Study participants with 2 study eyes are assigned to the non-sham group. Multiple events within a study participant are only counted once per event.

^§Four of the 6 vascular deaths in the sham group, 1 of the 8 vascular deaths in the ranibizumab group, and 1 of the 4 vascular deaths in the triamcinolone group were from an unknown cause.