Table 4.

Alternative Treatments Received for Diabetic Macular Edema

	Sham + Prompt Laser N = 293	Ranibizumab + Prompt Laser N = 187	Ranibizumab + Deferred Laser N = 188	Triamcinolone + Prompt Laser N = 186
Prior to the 1 year visit
Eyes with alternative treatments (number of treatments applied)	14 (25)	1 (1)	0	1 (1)
Per protocol, no.*	5	1	0	1
Deviations from protocol, no.	9	0	0	0
Alternative treatments, no.†
Intravitreal Bevacizumab	3	0	0	1
Intravitreal Triamcinolone Acetonide	5	1	0	0
Vitrectomy	2	0	0	0
Intravitreal Bevacizumab + Intravitreal Triamcinolone Acetonide	4	0	0	0
1 year through prior to the 2 year visit
Eyes with alternative treatments (number of treatments)	29 (55)	1 (1)	0	3 (4)
Per protocol, no.*	20	1	0	2
Deviations from protocol, no.	9	0	0	1
Alternative Treatments, no.†
Intravitreal Bevacizumab	9	0	0	0
Intravitreal Ranibizumab	2	0	0	0
Intravitreal Triamcinolone Acetonide	12	1	0	2‡
Vitrectomy	2	0	0	0
Vitrectomy + Intravitreal Triamcinolone Acetonide	0	0	0	1
Intravitreal Bevacizumab + Intravitreal Ranibizumab	1	0	0	0
Intravitreal Bevacizumab + Intravitreal Triamcinolone Acetonide	2	0	0	0
Intravitreal Bevacizumab + Intravitreal Ranibizumab + Intravitreal Triamcinolone Acetonide	1	0	0	0

^*Per protocol if met failure. Failure is defined as: Visual acuity 10 or more letters worse than baseline, optical coherence tomography central subfield thickness ≥250 microns, diabetic macular edema present on clinical exam that is the cause of the visual loss, complete laser given AND ≥13 weeks since last laser treatment with no improvement since the last laser treatment

^†Number of eyes, each combination of treatment only counted once

^‡Non-study drug was given (intravitreal Kenalog)