Table I.

Differential T cell cytokine profile between CCR5^+/+-- and CCR5^−/−-activated T cells^a

	CCR5+/+		CCR5−/−
Parameter	Median	Range	Median	Range
FGF-basic (fibroblast growth factor–basic), ng/ml	0.75	0.70–0.82	0.47	0.40–0.62
IL-11, pg/ml	5.32	4.1–6.5	Und.b	Und.–0.3
IL-2, pg/ml	116.00	73–162	25.90	12–30
IL-3, pg/ml	7.02	4.8–12	1.98	1.3–4.0
IL-6, pg/ml	6.81	1.5–17	1.97	Und.–4.2
MCP-1, pg/ml	0.78	0.62–2.9	Und.	Und.–0.53
MCP-3, pg/ml	1.53	1.2–2.2	0.70	0.57–1.1
M-CSF, ng/ml	0.0092	0.0071–0.01	0.0038	0.0028–0.0069
MIP-1γ, ng/ml	0.027	0.021–0.097	0.013	0.0072–0.014
MPO (myeloperoxidase), ng/ml	0.56	0.38–1.7	0.12	0.066–0.19
OSM (oncostatin M), ng/ml	0.03	0.024–0.03	0.02	0.022–0.023
SCF (stem cell factor), pg/ml	11.50	9.7–15	6.17	4.5–8.8
TIMP-1 (tissue inhibitor of metalloproteinase    type 1), ng/ml	0.051	0.051–0.064	0.047	0.037–0.045

^aChemokine-cytokine and other biomarker concentrations were measured in culture supernatants of purified mouse T cells after 48 h of stimulation with anti-CD3/CD28 Abs. Three mice per group were analyzed. Only those cytokines are listed for which significant differences in their levels were detected between CCR5^+/+ and CCR5^−/− T cell culture supernatants (p < 0.05). The complete list of biomarkers assessed and their corresponding levels detected in CCR5^+/+ and CCR5^−/− mice are shown in supplemental Table 1. Data were obtained by Rules-Based Medicine (www.rulesbasedmedicine.com), a multianalyte profile bioassay (31, 41–43).

^bUnd. indicates undetectable.