Table 3.
Test materials | Dose (mg/kg) | Mass of intestinal fluid (×10-2 g/cm) | Volume of intestinal fluid (×10-2 ml/cm) | % inhibition of intraluminal fluid accumulation |
---|---|---|---|---|
Saline control | 0 | 3.54 ± 0.94 | 3.43 ± 0.31 | 0.00 |
Diphenoxylate HCla | 2.5 | 0.76 ± 0.14* | 0.55 ± 0.21* | 83.76 |
Loperamide | 2.5 | 0.96 ± 0.19* | 0.72 ± 0.32* | 79.00 |
Methanol extract# | 100 | 2.27 ± 0.21* | 2.34 ± 0.23* | 31.77 |
200 | 1.68 ± 0.16* | 1.69 ± 0.22* | 50.72 | |
400 | 1.27 ± 0.14* | 1.11 ± 0.19* | 67.36 |
Values are means ± SD; n = 8 in each group;
Significantly different from the saline control (P ≤ 0.001) Duncan test; The saline control was made 0% inhibition of intraluminal accumulation to reveal better the effects of the other test materials.;
The methanol extract of T. madagascariens;
The reference drugs were diphenoxylate HCl and loperamide.