Table 3.

Effect of test materials at various doses on mass and volume of intestinal fluids in rats

Test materials	Dose (mg/kg)	Mass of intestinal fluid (×10-2 g/cm)	Volume of intestinal fluid (×10-2 ml/cm)	% inhibition of intraluminal fluid accumulation
Saline control	0	3.54 ± 0.94	3.43 ± 0.31	0.00
Diphenoxylate HCla	2.5	0.76 ± 0.14*	0.55 ± 0.21*	83.76
Loperamide	2.5	0.96 ± 0.19*	0.72 ± 0.32*	79.00
Methanol extract#	100	2.27 ± 0.21*	2.34 ± 0.23*	31.77
	200	1.68 ± 0.16*	1.69 ± 0.22*	50.72
	400	1.27 ± 0.14*	1.11 ± 0.19*	67.36

Values are means ± SD; n = 8 in each group;

^*Significantly different from the saline control (P ≤ 0.001) Duncan test; The saline control was made 0% inhibition of intraluminal accumulation to reveal better the effects of the other test materials.;

^#The methanol extract of T. madagascariens;

^aThe reference drugs were diphenoxylate HCl and loperamide.