Table 5.
Treatment | Dose (mg/kg) |
Biochemical parameters |
|||||||
---|---|---|---|---|---|---|---|---|---|
Serum |
Cardiac proteins (mg/g) | Hepatic proteins (mg/g) | |||||||
RBC (mm-3) | WBC (mm-3) | Hematocrit | Creatinine (μmol/L) | Triglyceride (mmol/L) | Proteins (mg/ml) | ||||
Saline control | 0 | 55940 ± 2865 | 416 ± 75 | 29.90 ± 1.79 | 40.75 ± 9.85 | 0.68 ± 0.16 | 28.73 ± 3.54 | 34.34 ± 8.25 | 95.46 ± 19.20 |
Methanol extract | 100 | 93,200 ± 9328* | 643 ± 145* | 36.80 ± 2.14* | 26.81 ± 5.65* | 1.50 ± 0.18* | 40.47 ± 3.88* | 57.7 ± 10.15* | 177.18 ± 40.10* |
n-hexane fraction | 80 | 58,320 ± 3267 | 458 ± 59 | 30.00 ± 1.05 | 38.61 ± 7.49 | 1.21 ± 0.15* | 31.06 ± 6.58 | 52.73 ± 14.19* | 130.63 ± 28.61* |
Ethyl acetate fraction | 80 | 91,830 ± 12,726* | 627 ± 94* | 36.10 ± 1.79* | 24.66 ± 1.58* | 1.74 ± 0.35* | 39.63 ± 1.04* | 68.49 ± 10.76* | 176.93 ± 16.05* |
n-butanol fraction | 80 | 83,090 ± 11,132* | 583 ± 122* | 32.10 ± 1.66* | 28.96 ± 7.24* | 1.29 ± 0.19* | 30.78 ± 6.79 | 56.64 ± 5.59* | 156.56 ± 47.68* |
Aqueous residue fraction | 80 | 56,430 ± 5228 | 242 ± 81 | 31.70 ± 1.88* | 32.17 ± 7.15* | 1.17 ± 0.39* | 34.02 ± 5.64* | 50.98 ± 8.98* | 131.15 ± 38.37* |
Loperamide | 2.5 | 95,870 ± 11,586* | 864 ± 87* | 38.80 ± 3.04* | 18.23 ± 7.24* | 1.73 ± 0.19* | 42.10 ± 2.77* | 69.94 ± 10.86* | 178.25 ± 8.22* |