Official websites use .gov
A
.gov website belongs to an official
government organization in the United States.
Secure .gov websites use HTTPS
A lock (
) or https:// means you've safely
connected to the .gov website. Share sensitive
information only on official, secure websites.
The S. cerevisiae Hrd1 ubiquitin ligase complex. Schematic representation of the Hrd1 complex in yeast that includes factors involved in substrate selection (Kar2 and Yos9), ubiquitination (Ubc7 and Cue1), and recruitment of cdc48 (Ubx2) and Der1 (Usa1). Yeast proteins are shown in black and their mammalian homologs are shown in magenta. Hrd1 complex components required for Insig-mediated degradation of HMG CoA reductase in Drosophila S2 cells are denoted by asterisks.
