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. 2010 Jul 16;192(18):4562–4570. doi: 10.1128/JB.00536-10

FIG. 2.

FIG. 2.

Characterization of the W/Beijing duplication through whole-genome microarray. Comparative array hybridizations were carried out for genomic DNA prepared from wild-type W/Beijing isolates G4B1.2 (A) and HN878 (B) versus H37Rv. For each, the average Z scores from three arrays for each of the 3,924 genes present in H37Rv are shown. The RD105 and RD207 deletions unique to the W/Beijing lineage are indicated, as are the RD150 and RD142 deletions that are characteristic of group 4 and 5 W/Beijing isolates, respectively. The RD3 and RD152 deletions were also identified. The majority of the ∼300 genes in the contiguous stretch from Rv3128c to Rv3427c showed a Z score of ≥2.0, consistent with the presence of a 350-kb duplicated region in G4B1.2 and HN878 relative to H37Rv.