TABLE 2.
Immunization groupa | Log10 antibody titerb |
IgG2a/IgG1 ratio | ||||
---|---|---|---|---|---|---|
IgG | IgG1 | IgG2a | IgG2b | IgG3 | ||
cOTC antigen + FA | 5.1 ± 0.007, 4.8 ± 0.031 | 3.9 ± 0.068, 3.6 ± 0.046 | 4.2 ± 0.009, 3.9 ± 0.02 | 4.5 ± 0.006, 4.5 ± 0.012 | 3.3 ± 0.007, 3.6 ± 0.0075 | 2, 2 |
PBS control | <2 | <2 | <2 | <2 | <2 |
FA, Freund's adjuvant.
Titers were determined by ELISA at days 15 and 30 after the last dose.