TABLE 2.
Virulence for mice of the Y. pestis recombinant strains after subcutaneous injection or aerosol exposure
| Strain | s.c. injection |
Aerosol exposure |
|||
|---|---|---|---|---|---|
| No. of CFU injected | No. of dead animals/total no. of animals infected | No. of suspension-nebulized CFU/ml | No. of dead animals/total no. of animals infected | Time to death (days) | |
| CO92p | 12 | 3/5 | (0.95 ± 0.3) × 108a | 12/12a | 4 ± 1a |
| CO92ΔR1pe | 10 | 3/5 | 1.1 × 108 | 6/6 | 4.5 |
| CO92ΔR2pe | 16 | 3/5 | 2 × 108 | 6/6 | 3 |
| CO92ΔR3pe | 12 | 3/5 | 1.5 × 108 | 6/6 | 3 |
| CO92ΔR4pe | 12 | 3/5 | 1.4 × 108 | 5/5 | 4 |
| CO92ΔR5pe | 9 | 3/5 | 1.4 × 108 | 6/6 | 3 |
| CO92ΔR6pe | 17 | 5/5 | 1.1 × 108 | 6/6 | 3 |
| CO92ΔCDS1pe | 14 | 5/5 | 0.9 × 108 | 6/6 | 4 |
| CO92ΔCDS2pe | 13 | 3/5 | 0.6 × 108 | 6/6 | 3 |
a
These values are means ± standard deviations for two experiments with six mice each.