TABLE 2.

Differential expression of the selected virulence-related Y. pestis genes during macrophage infection

Gene location and locus tag	Predicted function	Symbol	Fold change in expression levela
			1.5 h	4 h	8 h
pCD1 plasmid
Y0009	Secreted protein kinase	ypkA	1.1	1.0	1.2
Y0010	Targeted effector protein	yopJ	−3.1	−2.5	−1.1
Y0013	Secreted effector protein	yopH	1.4	1.2	2.0
Y0050	Secreted effector protein	lcrV	−2.7	−1.1	1.0
Y0052	Secreted effector protein	yopB	−1.0	1.1	1.2
Y0053	Secreted effector protein	yopD	−1.3	−1.0	−1.0
Y0059	Yop targeted effector protein	yopM	−7.9	−3.6	−1.5
Y0065	Yop targeted effector	yopT	−1.3	−1.3	1.0
Y0066	Yop targeting protein	yopK	−1.8	−1.2	1.4
Y0077	Secreted effector	yopE	1.0	1.1	1.4
pPCP1 plasmid, YPKp07	Plasminogen activator protease precursor	pla	2.8	1.3	2.8
pMT1 plasmid
YPKMT065	F1 capsule antigen	caf1	−4.2	−1.5	−1.1
YPKMT066	F1 capsule protein	caf1A	−19.9	−6.8	−2.4
YPKMT067	F1 capsule protein	caf1M	−13.5	−7.8	−5.0
Y1097	F1 capsule positive regulator	caf1R	−3.2	−4.3	−2.1
YPKMT083	Murine toxin	tox	−1.8	−1.6	−2.2
Chromosomal
y2880	Outer membrane usher protein	psaC	19.1	18.0	9.6
y2881	pH 6 antigen chaperone protein	psaB	20.5	11.7	5.1
y2882	pH 6 antigen fimbrial subunit	psaA	22.1	15.4	40.3
y2883	Hypothetical protein	psaF	1.7	1.7	1.5
y2884	Putative regulator	psaE	1.6	2.0	1.5
y0183	Putative toxin subunit	tcaA1	7.6	6.6	2.4
y0184	Putative toxin subunit	tcbA	3.9	5.6	2.3
y0185	Putative toxin subunit	tcaC1	1.7	1.8	1.3

^aThe fold changes with P values of <0.05 are indicated in boldface.