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. 2010 Jul 6;30(17):4134–4148. doi: 10.1128/MCB.00154-10

FIG. 9.

FIG. 9.

MRTF-A participates in AngII-induced hypertrophic signaling in vivo. (A) SBP (mm Hg) in wild-type (wt) and MRTF-A−/− (null) mice, with or without AngII infusion for 2 weeks (n = 4 each for wild-type mice and 8 each for MRTF-A−/− mice). (B) HW/BW ratios (mg/g) in wt and MRTF-A−/− mice, with or without AngII infusion for 2 weeks (10 to 12 weeks of age; n = 4 each for wild-type mice and 8 each for MRTF-A−/− mice). (C) Hearts were sectioned coronally and stained with hematoxylin-eosin. Scale bar, 1 mm. (D to H) BNP (D), skeletal α-actin (SKA) (E), myocardin (myoc) (F), MRTF-B (G), or MRTF-A (H) gene expression was assessed by real-time RT-PCR using total RNA extracted from wt and MRTF-A−/− mice, with or without AngII for 2 weeks (n = 3 for wild-type mice without AngII, 4 for wild-type mice with AngII, 5 for MRTF-A−/− mice without AngII, and 6 for MRTF-A−/− mice with AngII). In all graphs, values are shown as means ± SEM; *, P < 0.05.