Interaction between maternal serum 5-methyltetrahydrofolate (5MeTHF) and 5-formyltetrahydrofolate (5FoTHF) on the risk of preterm birth (n = 313; P = 0.01). Serum 5MeTHF concentrations were chosen at the 10th, 50th, and 90th percentiles of the distribution, and 5FoTHF concentrations were chosen at the 10th, 25th, 50th, 75th, and 90th percentiles of the distribution. Risk ratios (RRs) were generated on the basis of linear combinations of the log-binomial regression-model coefficients by using the concentrations of 5FoTHF and 5MeTHF provided. All RRs were adjusted for race-ethnicity, smoking before pregnancy, education, and obesity.