TABLE 3.
Relative risk (RR) of incident gout according to caffeine intake
| Caffeine intake (quintiles) | No. of cases | Person-years | Age-adjusted RR (95% CI) | Multivariate RR (95% CI)1 |
| ≤131 mg/d | 226 | 425,396 | 1.0 | 1.0 |
| 132–238 mg/d | 207 | 426,508 | 0.89 (0.74, 1.08) | 0.84 (0.70, 1.02) |
| 239–358 mg/d | 220 | 425,553 | 0.95 (0.79, 1.14) | 0.91 (0.75, 1.10) |
| 359–497 mg/d | 158 | 427,028 | 0.79 (0.64, 0.97) | 0.77 (0.62, 0.94) |
| ≥498 mg/d | 85 | 427,663 | 0.49 (0.38, 0.63) | 0.52 (0.41, 0.68) |
| P value for trend | — | — | <0.001 | <0.001 |
1
Adjusted for age, total energy intake, BMI, menopause, use of hormonal replacement, diuretic use, history of hypertension, and intakes of alcohol, total meats, seafood, total vitamin C, and dairy foods. Values were computed by using a Cox proportional hazards model.