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Electrostatic surface representation of the integrase catalytic core. (A) G118R and E138K structure. On the surface, red represents negatively charged elements, white represents neutral elements, and blue represents positively charged elements. Green, Mg2+ cation. Underneath the semitransparent surface, side chains and amino acids 64, 116, 118, and 138 are shown. The arrow indicates amino acids 118 and 138 and the area of charge change as a result of the amino acid substitution.
