FIG. 6.

Network analysis of nuclear proteins which have been oxidized by RSV infection in Prdx-1- or Prdx-4-silenced A549 cells. Shown is the molecular interaction network program using the 15 unique proteins found to be most oxidized by RSV infection as the input. Note that all 15 unique proteins occur in the network (gray). ALDH1B1, aldehyde dehydrogenase 1 family, member B1; ANXA2, annexin A2; ATF4, activating transcription factor 4 (tax-responsive enhancer element B67); ATP5A1, ATP synthase, H⁺ transporting, mitochondrial F1 complex, alpha subunit 1, cardiac muscle; CDC42SE1, CDC42 small effector 1; CENPE, centromere protein E, 312 kDa; CEP290, centrosomal protein, 290 kDa; CPS1, carbamoyl-phosphate synthetase 1, mitochondrial; DSP, desmoplakin; ERBB2, v-erb-b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma-derived oncogene homolog (avian); GFAP, glial fibrillary acidic protein; GOT2, glutamic-oxaloacetic transaminase 2, mitochondrial (aspartate aminotransferase 2); HADHA, hydroxyacyl-coenzyme A dehydrogenase/3-ketoacyl-coenzyme A thiolase/enoyl-coenzyme A hydratase (trifunctional protein), alpha subunit; HSPA9, heat shock 70-kDa protein 9 (mortalin); IMPACT, impact homolog (mouse); LEP, leptin; LMNA, Lam A/C; LRPPRC, leucine-rich PPR-motif containing; MAPK8, mitogen-activated protein kinase 8; MYC, v-myc myelocytomatosis viral oncogene homolog (avian); NFKB2, nuclear factor of kappa light polypeptide gene enhancer in B cells 2 (p49/p100); NNMT, nicotinamide N-methyltransferase; PAK1IP1, PAK1 interacting protein 1; PPL, periplakin; Prdx5, peroxiredoxin 5; PRL2C3, prolactin family 2, subfamily c, member 3; RPL17, ribosomal protein L17; SLC11A1, solute carrier family 11 (proton-coupled divalent metal ion transporters), member 1; SOLH, small optic lobes homolog (Drosophila); SP1, Sp1 transcription factor; SPAG4, sperm-associated antigen 4; SQRDL, sulfide quinone reductase-like (yeast); STMN3, stathmin-like 3; TGFB1, transforming growth factor, beta 1.