TABLE 2.
Characterization of MAb neutralization of SF162 viral variants
| Antibody | SF162 |
SHIV-SF162P4 |
||||
|---|---|---|---|---|---|---|
| Clone 41.1 |
||||||
| IC50 (μg/ml) | IC80 (μg/ml) | IC50 (μg/ml) | IC80 (μg/ml) | IC50 (μg/ml) | IC80 (μg/ml) | |
| sCD4 | 0.35 | 1.39 | 0.40 | 1.90 | 0.16 | 0.62 |
| b12 | 0.05 | 0.27 | 0.14 | 0.73 | 0.05 | 0.16 |
| F105 | 26.3 | >50 | 31.2 | >50 | 5.9 | >50 |
| 17b | 25.4 | >50 | 28.0 | >50 | 5.7 | >50 |
| 48d | >50 | >50 | >50 | >50 | >50 | >50 |
| 2G12 | 0.46 | 3.29 | 16.8 | >50 | 1.80 | 16.0 |
| 447 | 0.10 | 1.90 | 0.35 | 5.59 | 0.11 | 1.21 |
| 39F | 0.03 | 0.36 | 0.07 | 1.03 | 0.03 | 0.26 |
| 4E10 | 1.4 | 14.0 | 18.1 | >50 | 3.7 | 22.0 |
| 2F5 | 0.85 | 5.44 | 31.8 | >50 | 1.52 | 6.4 |
| HIV Ig | 16.1 | 81.4 | 79.7 | 376 | 16.1 | 83.8 |