FIG. 2.

Effects of decitabine and gemcitabine on HIV infectivity. (a) The single-cycle HIV assay was used to assess viral infectivity as shown in Fig. 1. Decitabine leads to a concentration-dependent decrease in HIV infectivity, as measured by expression of HSA and GFP by flow cytometry. The data were normalized by setting the untreated control cells (ND, no drug) to 100% infectivity and comparing all of the other treatment groups to this value. (b) Dose response of HIV infectivity to gemcitabine. The data shown are means ± SDs. Each data point is from three independent experiments.