TABLE 4.
Types of JCV RRs found in brain, kidney, bone, spleen, and lymph node FFPE samples from HIV-positive PML, HIV-positive, and HIV-negative individuals
| Sample type | Group | No. of patients | No. of clones | No. of RRs of the indicated type/no. of clones sequenced (%)a |
|||
|---|---|---|---|---|---|---|---|
| I-S | I-R | II-S | II-R | ||||
| Brain | HIV positive/PML | 6 | 28 | 3/28 (11) | 13/28 (46) | 12/28 (43) | 0 |
| HIV positive | 2 | 19 | 4/19 (21) | 15/19 (79) | 0 | 0 | |
| HIV negative | 3 | 21 | 9/21 (43) | 12/21 (57) | 0 | 0 | |
| Kidney | HIV positive/PML | 2 | 19 | 0 | 19/19 (100) | 0 | 0 |
| HIV positive | 0 | 0 | NA | NA | NA | NA | |
| HIV negative | 0 | 0 | NA | NA | NA | NA | |
| Bone | HIV positive/PML | 3 | 20 | 10/20 (50) | 10/20 (50) | 0 | 0 |
| HIV positive | 3 | 25 | 0 | 6/25 (24) | 9/25 (36) | 10/25 (40) | |
| HIV negative | 0 | 0 | NA | NA | NA | NA | |
| Spleen | HIV positive/PML | 4 | 32 | 2/32 (6) | 16/32 (50) | 14/32 (44) | 0 |
| HIV positive | 7 | 65 | 10/65 (15) | 43/65 (66) | 12/65 (18) | 0 | |
| HIV negative | 3 | 30 | 0 | 0 | 30/30 (100) | 0 | |
| Lymph node | HIV positive/PML | 2 | 19 | 0 | 9/19 (47) | 10/19 (53) | 0 |
| HIV positive | 4 | 33 | 3/33 (9) | 26/33 (79) | 4/33 (12) | 0 | |
| HIV negative | NA | NA | NA | NA | NA | NA | |
a
NA, not available.