TABLE 8.
Clinical sensitivities and specificities of three assaysa for N. gonorrhoeae
| Specimen typeb and symptom status | % sensitivity (range) |
% specificity (range) |
||||
|---|---|---|---|---|---|---|
| ABT m2000 | GP AC2 | BD ProbeTec | ABT m2000 | GP AC2 | BD ProbeTec | |
| Endocervical | ||||||
| Symptomatic | 87.1 (70.2-96.4) | 90.6 (75.0-98.0) | 87.5 (71.0-96.5) | 99.7 (99.0-100.0) | 99.4 (98.6-99.8) | 99.6 (98.8-99.9) |
| Asymptomatic | 91.3 (72.0-98.9) | 90.9 (70.8-98.9) | 91.3 (72.0-98.9) | 100.0 (99.5-100.0) | 99.7 (99.0-100.0) | 98.9 (97.8-99.6) |
| CC vaginal | ||||||
| Symptomatic | 96.8 (83.3-99.9) | 93.8 (79.2-99.2) | NAc | 99.9 (99.2-100.0) | 99.3 (98.4-99.8) | NA |
| Asymptomatic | 95.7 (78.1-99.9) | 95.7 (78.1-99.9) | NA | 99.4 (98.5-99.8) | 99.7 (98.9-100.0) | NA |
| SC vaginal | ||||||
| Symptomatic | 96.7 (82.8-99.9) | NA | NA | 99.7 (98.9-100.0) | NA | NA |
| Asymptomatic | 95.7 (78.1-99.9) | NA | NA | 100.0 (99.4-100.0) | NA | NA |
| Female urine | ||||||
| Symptomatic | 93.8 (79.2-99.2) | 84.4 (67.2-94.7) | 76.7 (57.7-90.1) | 99.7 (99.0-100.0) | 99.6 (98.8-99.9) | 95.6 (93.7-97.0) |
| Asymptomatic | 87.0 (66.4-97.2) | 82.6 (61.2-95.0) | 85.7 (63.7-97.0) | 99.6 (98.7-99.9) | 99.4 (98.5-99.8) | 96.9 (95.3-98.1) |
| Urethral | ||||||
| Symptomatic | 99.2 (97.0-99.9) | 99.2 (97.0-99.9) | NA | 99.3 (98.3-99.8) | 99.2 (98.1-99.7) | NA |
| Asymptomatic | 81.8 (48.2-99.7) | 81.8 (48.2-97.7) | NA | 99.8 (99.1-100.0) | 99.7 (98.9-100.0) | NA |
| Male urine | ||||||
| Symptomatic | 98.8 (96.4-99.7) | 97.9 (95.2-99.3) | 94.9 (91.3-97.3) | 99.5 (98.5-99.9) | 99.7 (98.8-100.0) | 97.0 (95.2-98.2) |
| Asymptomatic | 100.0 (71.5-100.0) | 100.0 (71.5-100.0) | 100.0 (69.2-100.0) | 100.0 (99.4-100.0) | 99.5 (98.7-99.9) | 95.7 (93.8-97.2) |
| All types | ||||||
| Symptomatic | 97.8 (96.3-98.8) | 97.1 (95.3-98.3) | 92.3 (88.6-95.0) | 99.6 (99.4-99.8) | 99.4 (99.1-99.7) | 97.5 (96.7-98.1) |
| Asymptomatic | 92.1 (85.5-96.3) | 90.0 (81.9-95.3) | 90.7 (79.7-96.9) | 99.8 (99.6-99.9) | 99.6 (99.3-99.8) | 97.2 (96.4-97.9) |
| Overall | 96.9 (95.4-98.1) | 96.1 (94.3-97.4) | 92.0 (88.7-94.6) | 99.7 (99.6-99.8) | 99.5 (99.3-99.7) | 97.3 (96.8-97.8) |
a
GP AC2, GenProbe Aptima Combo 2; BD ProbeTec, Becton Dickinson ProbeTec; ABT m2000, Abbott m2000.
b
CC, clinician collected; SC, self-collected.
c
NA, not applicable.