TABLE 2.
Age and toxin gene distributions of colonization factors of ETEC strains
| CF type | No. (%) of children |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| <12 mo |
12-24 mo |
All ages |
Toxin gene type |
All strains (n = 85) | ||||||
| Diarrhea (n = 32) | Control (n = 4) | Diarrhea (n = 26) | Control (n = 23) | Diarrhea (n = 58) | Control (n = 27) | LT (n = 48) | ST (n = 21) | LT-ST (n = 16) | ||
| CFA/I | 2 (6) | 1 (4) | 2 (3) | 1 (4) | 3 (14) | 3 (4) | ||||
| CS1 | 1 (3) | 4 (15) | 1 (4) | 5 (9) | 1 (4) | 1 (5) | 5 (31) | 6 (7) | ||
| CS5 | 3 (12) | 3 (5) | 3 (14) | 3 (4) | ||||||
| CS6 | 6 (19) | 2 (8) | 2 (9) | 8 (14) | 2 (7) | 10 (48) | 10 (12) | |||
| CS7 | 2 (6) | 1 (4) | 1 (4) | 3 (5) | 1 (4) | 4 (8) | 4 (5) | |||
| CS8 | 1 (3) | 1 (2) | 1 (2) | 1 (1) | ||||||
| CS12 | 2 (6) | 5 (19) | 1 (4) | 7 (12) | 1 (4) | 3 (6) | 5 (31) | 8 (9) | ||
| CS17 | 1 (3) | 1 (4) | 2 (9) | 2 (3) | 2 (7) | 4 (8) | 4 (5) | |||
| CS18 | 1 (4) | 1 (2) | 1 (2) | 1 (1) | ||||||
| CS19 | 1 (4) | 1 (4) | 1 (2) | 1 (1) | ||||||
| CS20 | 1 (4) | 1 (2) | 1 (2) | 1 (1) | ||||||
| PCF071 | 1 (3) | 1 (2) | 1 (2) | 1 (1) | ||||||
| Ag150 | 1 (3) | 1 (4) | 1 (2) | 1 (4) | 2 (4) | 2 (2) | ||||
| Fim4089 | 1 (3) | 1 (4) | 2 (3) | 2 (4) | 2 (2) | |||||
| Mixed CFsa | 1 (3) | 0 (0) | 3 (12) | 1 (4) | 4 (7) | 1 (4) | 3 (6) | 1 (5) | 1 (6) | 5 (6) |
| CFs detectedb | 18 (56) | 0 (0) | 19 (73) | 10 (43) | 37 (64) | 10 (37)c | 20 (42) | 17 (81)d | 10 (63) | 47 (55) |
| CFs undetectede | 15 (47) | 4 (100) | 10 (38) | 14 (61) | 25 (43) | 18 (67) | 31 (65) | 5 (24) | 7 (44) | 43 (51) |
a
Five strains showed two CFs, including four from diarrheal samples: ETEC-LT with CS8 and Ag150, ETEC-LT with CS7 and CS18, ETEC-LT-ST with CS1 and CS12, and ETEC-ST with CS5 and CS6. Only one mixed-CF strain was isolated from a control sample: LT-ETEC with CS17 and CS19.
b
Including strains with mixed CFs.
c
P < 0.05 for the comparison between diarrheal and control samples for all ages.
d
P < 0.05 for the comparison between ST- and LT-producing strains.
e
CFs were undetected with the panel of 21 monoclonal antibodies used.