TABLE 1.
DIVA sensitivity and specificity ROC estimates for SICCT and defined protein cocktail-based skin tests
| Diagnostic antigen | Cutoff (mm) | Sensitivity (%)a | Specificity (%)b | Area under the curve | 95% CId |
|---|---|---|---|---|---|
| SICCT (PPD-B-A) | >2 | 100 | 15.0 | 0.899 | 0.817-0.981 |
| SICCT (PPD-B-A) | >4 | 94.1 | 40.0 | 0.899 | 0.817-0.981 |
| SICCT (PPD-B-A) | >10 | 55.9 | 100 | 0.899 | 0.817-0.981 |
| Protein cocktailc | >1 | 73.6 | 100 | 0.882 | 0.791-0.974 |
a
Sensitivity determined by using naturally infected “reactor” cattle with diseased confirmed by SICCT (n = 34).
b
Specificity determined by using disease-free BCG-vaccinated calves (n = 20).
c
Protein cocktail comprised of 10 μg of ESAT-6, CFP-10, MPB70, and MPB83.
d
CI, confidence interval.