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The expected frequencies of single (A), double (B), triple (C), and quadruple and quintuple (D) mutants in proviral DNA predicted by our simulations (dark gray bars) and our deterministic model (equations 2 to 6) (light gray bars). Error bars represent standard deviations. The parameter values employed are mentioned in Materials and Methods. The corresponding frequencies in cell-free viral RNA are shown in Fig. S6 in the supplemental material.
