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. 2010 Jul 21;84(19):9879–9888. doi: 10.1128/JVI.00320-10

FIG. 1.

FIG. 1.

(A and B) Association of HLA allele expression with steady-state viral load (A) and absolute CD4 count (B) in a cohort of 1,211 HIV C-clade chronically infected individuals from KwaZulu-Natal, South Africa. Left-hand panels show association of all alleles occurring at a phenotypic frequency of greater than 1%. Associations with a P value of <0.05 (as measured by a Mann-Whitney U test) are highlighted in yellow, and those retaining significance after Bonferroni correction for multiple comparisons are highlighted in blue. Right-hand panels show the relative contribution of HLA-A, -B, and -C alleles to variation in viral load and CD4 count as measured by the Kruskal-Wallis test statistic (H). (C and D) Association of HLA allele expression with steady-state viral load (C) and absolute CD4 count (D), excluding the four alleles most strongly associated with differences in viral load and CD4 count (HLA-B*57, -B*5801, -B*18, and -B*5802). A total of 682 subjects were analyzed.