TABLE 1.

Association between HLA alleles and VL

Allele	Association with entire cohorta		Association with exclusion of top four allelesb
	Median VL	P value	Median VL	P value
HLA-A
A0101	29,700	0.424	41,800	0.918
A0201	75,100	0.108	64,500	0.141
A0202	26,900	0.426	26,128	0.657
A0205	18,400	0.001	54,400	0.859
A0301	49,300	0.149	44,300	0.439
A2301	50,450	0.169	44,369	0.382
A2402	23,200	0.23	26,600	0.994
A2601	51,100	0.927	51,100	0.883
A29	38,300	0.643	30,000	0.601
A3001	42,035	0.297	42,850	0.529
A3002	44,100	0.654	31,750	0.503
A3004	53,500	0.195	28,300	0.702
A3201	1E+05	0.32	162,000	0.154
A33	26,050	0.137	17,868	0.093
A3402	38,200	0.927	39,061	0.844
A3601	38,550	0.631	15,100	0.582
A4301	47,850	0.204	33,800	0.524
A6601	60,400	0.152	14,700	0.018
A6801	20,000	0.004	23,200	0.065
A6802	73,900	0.456	88,150	0.25
A7401	41,000	9E-04	40,250	0.327
A6602	19,000	0.573	25,954	0.825
A8001	92,250	0.108
HLA-B
B0702	28,300	0.21425	26,500	0.281
B0705	100,000	0.1044	143,000	0.085
B0801	50,950	0.10076	61,088	0.02
B13	12,700	0.02711	22,500	0.222
B1401	27,600	0.10719	14,360	0.14
B1402	57,700	0.67348	26,128	0.643
B1503	53,350	0.0167	55,300	0.004
B1510	66,350	0.03362	61,900	0.037
B1516	19,050	0.67152	12,010	0.307
B18	92,500	0.00005
B35	37,900	0.80593	30,000	0.527
B3910	18,400	0.02571	12,000	0.008
B4101	129,000	0.17934	129,000	0.227
B4201	26,150	0.00884	26,000	0.028
B4202	92,700	0.30147	92,700	0.173
B4403	25,500	0.01917	24,579	0.091
B4501	76,200	0.01804	63,900	0.136
B4901	91,000	0.08138	52,700	0.38
B51	70,900	0.38697	45,798	0.896
B5301	33,550	0.89029	24,363	0.916
B5702	14,145	0.00285
B5703	5,528	1.30E-08
B5801	18,400	0.0002
B5802	75,900	4.60E-08
B8101	19,400	0.00864	20,500	0.052
HLA-C
Cw02	44,795	0.08726	42,585	0.24
Cw0302	15,000	0.01133
Cw0304	55,900	0.63502	45,000	0.944
Cw0401	29,850	0.03646	25,500	0.041
Cw0501	38,200	0.31217
Cw0602	64,200	5.90E-07	31,200	0.464
Cw0701	31,400	0.06595	44,369	0.079
Cw0702	31,600	0.57478	32,700	0.817
Cw0704	84,900	0.0122
Cw0801	43,369	0.94714	42,300	0.874
Cw0802	34,750	0.42796	26,864	0.497
Cw0804	55,800	0.26745	40,600	0.359
Cw1203	14,750	0.001	6,055	1E-04
Cw1601	75,000	0.12564	76,900	0.074
Cw1701	1E+05	0.12763	33,200	0.245
Cw1801	33,500	0.08234	35,750	0.637
Cw1604	24,157	0.16371

^aExact P values for association between HLA alleles and steady-state viral load are given. All P values represent Mann-Whitney U tests between all individuals possessing and all individuals lacking a given HLA allele. All associations significant at a P value of <0.05 are highlighted in boldface, and those that remain significant following Bonferroni correction are underlined.

^bMann-Whitney U tests were carried out following exclusion of the four strongest HLA associations: HLA-B*57, HLA-B*5801, HLA-B*18, and HLA-B*5802.