TABLE 2.
Association between HLA alleles and absolute CD4 count
| Allele | Association with entire cohorta |
Association with exclusion of top four allelesb |
||
|---|---|---|---|---|
| Median CD4 count | P value | Median CD4 count | P value | |
| HLA-A | ||||
| A0101 | 414.5 | 0.23697 | 431 | 0.16141 |
| A0201 | 336 | 0.43918 | 376 | 0.86264 |
| A0202 | 447 | 0.26649 | 447 | 0.54073 |
| A0205 | 413.5 | 0.0025 | 382 | 0.34923 |
| A0301 | 328 | 0.03674 | 308 | 0.00792 |
| A2301 | 368 | 0.2267 | 370 | 0.53177 |
| A2402 | 360.5 | 0.74159 | 361.5 | 0.63343 |
| A2601 | 445 | 0.13058 | 423 | 0.28828 |
| A29 | 375 | 0.95601 | 396 | 0.45789 |
| A3001 | 362.5 | 0.3199 | 368.5 | 0.39151 |
| A3002 | 367 | 0.86507 | 377.5 | 0.82533 |
| A3004 | 341.5 | 0.29507 | 352 | 0.42233 |
| A3201 | 347 | 0.21075 | 347 | 0.25617 |
| A33 | 472.5 | 0.00859 | 480 | 0.00731 |
| A3402 | 415.5 | 0.04498 | 419 | 0.14516 |
| A3601 | 307 | 0.34355 | ||
| A4301 | 351 | 0.65896 | 363 | 0.86161 |
| A6601 | 307 | 0.05149 | 413 | 0.73452 |
| A6801 | 363 | 0.05781 | 316 | 0.08029 |
| A6802 | 310 | 0.81802 | 265.5 | 0.50581 |
| A7401 | 377 | 0.29202 | 371 | 0.6329 |
| A6602 | 399 | 0.69335 | 383 | 0.27032 |
| A8001 | 352 | 0.28678 | ||
| HLA-B | ||||
| B0702 | 366 | 0.3095 | 363.5 | 0.17576 |
| B0705 | 288 | 0.2504 | 272 | 0.06472 |
| B0801 | 322.5 | 0.03477 | 316 | 0.00798 |
| B13 | 431 | 0.24477 | 421.5 | 0.40309 |
| B1401 | 419 | 0.05833 | 420.5 | 0.07777 |
| B1402 | 408 | 0.28425 | 448 | 0.3488 |
| B1503 | 346 | 0.02963 | 355.5 | 0.01608 |
| B1510 | 333 | 0.01858 | 358.5 | 0.12639 |
| B1516 | 333 | 0.389 | 333 | 0.60262 |
| B18 | 285 | 0.00002 | ||
| B35 | 443 | 0.05023 | 465.5 | 0.03043 |
| B3910 | 436 | 0.02863 | 448.5 | 0.06529 |
| B4101 | 230.5 | 0.00291 | 230.5 | 0.0251 |
| B4201 | 401.5 | 0.20828 | 397 | 0.64474 |
| B4202 | 347 | 0.37401 | 366.5 | 0.58821 |
| B4403 | 427.5 | 0.00061 | 430.5 | 0.00206 |
| B4501 | 324.5 | 0.13118 | 337.5 | 0.64015 |
| B4901 | 365 | 0.7138 | 340 | 0.405 |
| B51 | 360 | 0.76569 | 420.5 | 0.71869 |
| B5301 | 408.5 | 0.68474 | 412 | 0.92665 |
| B5702 | 704 | 0.00001 | ||
| B5703 | 503 | 4.80E-07 | ||
| B5801 | 429 | 0.0001 | ||
| B5802 | 318 | 2.20E-07 | ||
| B8101 | 455.5 | 0.0002 | 465 | 0.00325 |
| HLA-C | ||||
| Cw02 | 331 | 0.00176 | 352 | 0.02147 |
| Cw0302 | 428 | 0.20997 | ||
| Cw0304 | 377 | 0.69318 | 373.5 | 0.85974 |
| Cw0401 | 426 | 0.00002 | 441 | 0.00004 |
| Cw0501 | 217 | 0.0062 | ||
| Cw0602 | 336 | 0.00004 | 381 | 0.74994 |
| Cw0701 | 398.5 | 0.0639 | 356 | 0.11071 |
| Cw0702 | 334.5 | 0.05211 | 338.5 | 0.04463 |
| Cw0704 | 293 | 0.19293 | ||
| Cw0801 | 365 | 0.37584 | 376.5 | 0.39944 |
| Cw0802 | 408 | 0.39674 | 427 | 0.36661 |
| Cw0804 | 360 | 0.61808 | 356 | 0.63007 |
| Cw1203 | 452 | 0.0014 | 508 | 0.00053 |
| Cw1601 | 336 | 0.10239 | 322 | 0.0795 |
| Cw1701 | 230 | 0.96497 | 387 | 0.78642 |
| Cw1801 | 386.5 | 0.00002 | 449.5 | 0.06443 |
| Cw1604 | 461.5 | 0.11381 | ||
a
Exact P values for association between HLA alleles and absolute CD4 count are given. All P values represent Mann-Whitney U tests between all individuals possessing and all individuals lacking a given HLA allele. All associations significant at a P value of <0.05 are highlighted in boldface, and those that remain significant following Bonferroni correction are underlined.
b
Mann-Whitney U tests were carried out following exclusion of the four strongest HLA associations: HLA-B*57, HLA-B*5801, HLA-B*18, and HLA-B*5802.