TABLE 1.
Source and name of N1 NA virus | Subtype | Yr isolated | Origin | Mean IC50 ± SD (nM)b |
---|---|---|---|---|
Ducksa | ||||
A/Mallard/Alberta/743/83 | H9N1 | 1983 | Canada | 20.40 ± 2.69 |
A/Blue-Winged Teal/Alberta/212/84 | H1N1 | 1984 | Canada | 9.01 ± 1.58 |
A/Mallard/TN/11464/85 | H1N1 | 1985 | USA | 39.75 ± 10.00 |
A/Blue-Winged Teal/LA/B228/86 | H1N1 | 1986 | USA | 5.98 ± 2.02 |
A/Mallard/Alberta/323/88 | H2N1 | 1988 | USA | 24.88 ± 11.16 |
A/Mallard/Alberta/253/90 | H6N1 | 1990 | Canada | 1.28 ± 0.34 |
A/Mallard/Alberta/107/91 | H3N1 | 1991 | USA | 12.11 ± 3.60 |
A/Mallard/Alberta/196/92 | H3N1 | 1992 | Canada | 22.75 ± 0.00 |
A/Pintail/Alberta/129/93 | H7N1 | 1993 | Canada | 0.81 ± 0.36 |
A/Mallard/Alberta/5/95 | H10N1 | 1995 | Canada | 1.82 ± 0.55 |
A/Mallard/Alberta/267/96 | H1N1 | 1996 | Canada | 56.70 ± 11.82 |
A/Mallard/Alberta/119/98 | H1N1 | 1998 | Canada | 4.35 ± 0.00 |
A/Mallard/Alberta/201/98 | H1N1 | 1998 | Canada | 13.40 ± 0.00 |
A/Mallard/Alberta/34/2001 | H7N1 | 2001 | Canada | 102.25 ± 3.80 |
A/Pintail/Alberta/210/2002 | H1N1 | 2002 | Canada | 8.50 ± 10.25 |
A/Mallard/Alberta/130/2003 | H4N1 | 2003 | Canada | 8.99 ± 6.40 |
A/Mallard/Alberta/88/2004 | H1N1 | 2004 | Canada | 99.17 ± 61.85 |
A/Mallard/Alberta/226/2004 | H3N1 | 2004 | Canada | 51.61 ± 14.43 |
A/Pintail/Alberta/68/2005 | H1N1 | 2005 | Canada | 40.57 ± 8.54 |
A/Pintail/Alberta/69/2005 | H1N1 | 2005 | Canada | 11.52 ± 3.65 |
A/Canvasback/Alberta/276/2005 | H1N1 | 2005 | Canada | 39.30 ± 8.81 |
A/Mallard/PA/454069-9/2006 | H5N1 | 2006 | USA | 2.33 ± 0.96 |
A/Mallard/MN/SG-000220/2007 | H6N1 | 2007 | USA | 7.36 ± 3.96 |
A/Green-Winged Teal/LA/SG-00090/2007 | H1N1 | 2007 | USA | 18.03 ± 8.36 |
A/Mallard/MN/AI07-3018/2007 | H1N1 | 2007 | USA | 29.61 ± 20.09 |
A/Mallard/MN/AI07-3019/2007 | H3N1 | 2007 | USA | 12.97 ± 2.85 |
A/Mallard/MN/AI07-3099/2007 | H3N1 | 2007 | USA | 12.83 ± 4.18 |
A/Mallard/MN/AI07-3100/2007 | H1N1 | 2007 | USA | 10.54 ± 2.97 |
A/Mallard/OH/510306-4/2007 | H5N1 | 2007 | USA | 6.55 ± 2.33 |
A/Mallard/MI/463796-7/2007 | H5N1 | 2007 | USA | 4.48 ± 1.17 |
A/Mallard/MN/AI07-3108/2007 | H3N1 | 2007 | USA | 6.39 ± 2.10 |
A/Mallard/MN/AI07-3124/2007 | H3N1 | 2007 | USA | 8.39 ± 2.45 |
A/Mallard/MN/AI07-3127/2007 | H1N1 | 2007 | USA | 5.11 ± 1.89 |
A/Mallard/MN/AI07-3136/2007 | H1N1 | 2007 | USA | 6.41 ± 3.39 |
A/Mallard/MN/AI07-3140/2007 | H1N1 | 2007 | USA | 7.50 ± 2.36 |
A/Mallard/MN/AI07-3189/2007 | H10N1 | 2007 | USA | 6.74 ± 4.38 |
A/Mallard/MN/SG-000220/2007 | H6N1 | 2007 | USA | 5.69 ± 3.12 |
A/Mallard/MN/SG-000223/2007 | H6N1 | 2007 | USA | 3.97 ± 2.68 |
A/Mallard/MN/SG-000170/2007 | H6N1 | 2007 | USA | 12.53 ± 3.84 |
A/Mallard/MN/SG-000214/2007 | H6N1 | 2007 | USA | 6.18 ± 1.81 |
A/Mallard/MN/SG-000104/2007 | H6N1 | 2007 | USA | 7.62 ± 3.82 |
A/Mallard/MN/SG-000105/2007 | H6N1 | 2007 | USA | 7.02 ± 2.56 |
A/Mallard/MN/SG-000121/2007 | H1N1 | 2007 | USA | 12.41 ± 2.43 |
A/Red Headed Duck/MN/SG-000123/2007 | H1N1 | 2007 | USA | 10.49 ± 2.25 |
A/Blue-Winged Teal/TX/SG-00087/2007 | H4N1 | 2007 | USA | 6.03 ± 2.11 |
A/Mallard/MI/463796-7/2007 | H5N1 | 2007 | USA | 4.48 ± 1.17 |
A/Mallard/OH/510306-4/2007 | H5N1 | 2007 | USA | 6.55 ± 2.33 |
A/Mallard/OH/4809/2008 | H1N1 | 2008 | USA | 8.58 ± 1.47 |
A/Mallard/MN/SG-00572/2008 | H3N1 | 2008 | USA | 8.83 ± 1.96 |
A/Mallard/MN/SG-00627/2008 | H1N1 | 2008 | USA | 6.95 ± 3.18 |
A/Mallard/MN/SG-00628/2008 | H1N1 | 2008 | USA | 4.91 ± 1.63 |
A/Northern Shoveler/MN/SG-00651/2008 | H1N1 | 2008 | USA | 8.80 ± 2.81 |
A/Northern Shoveler/MN/SG-00655/2008 | H1N1 | 2008 | USA | 9.39 ± 4.22 |
A/Northern Shoveler/MN/SG-00661/2008 | H3N1 | 2008 | USA | 8.15 ± 2.41 |
A/Northern Shoveler/MN/SG-00665/2008 | H3N1 | 2008 | USA | 11.40 ± 4.95 |
A/Mallard/MN/AI08-3825/2008 | H5N1 | 2008 | USA | 9.56 ± 4.80 |
A/Mallard/MN/AI08-4507/2008 | H3N1 | 2008 | USA | 7.56 ± 4.44 |
A/Green-Winged Teal/AI08-4655/2008 | H5N1 | 2008 | USA | 1.87 ± 0.73 |
A/Mallard/MN/AI08-5384/2008 | H5N1 | 2008 | USA | 12.00 ± 1.14 |
Shorebirds/gullsa | ||||
A/Gull/Kazakhstan/870/79 | H1N1 | 1979 | USSR | 3.07 ± 0.91 |
A/Ruddy Turnstone/NJ/61/85 | H11N1 | 1985 | USA | 23.97 ± 6.89 |
A/Herring Gull/DE/698/88 | H2N1 | 1988 | USA | 10.85 ± 0.14 |
A/Ruddy Turnstone/DE/34/93 | H2N1 | 1993 | USA | 41.13 ± 15.51 |
A/Ruddy Turnstone/DE/78/93 | H11N1 | 1993 | USA | 10.05 ± 0.85 |
A/Ruddy Turnstone/DE/8/93 | H2N1 | 1993 | USA | 14.22 ± 10.33 |
A/Laughing Gull/DE/254/93 | H13N1 | 1993 | USA | 0.50 ± 0.21 |
A/Ruddy Turnstone/DE/81/93 | H2N1 | 1993 | USA | 23.97 ± 6.89 |
A/Ruddy Turnstone/DE/170/94 | H3N1 | 1994 | USA | 0.98 ± 0.46 |
A/Ruddy Turnstone/DE/185/94 | H3N1 | 1994 | USA | 3.59 ± 1.41 |
A/Ruddy Turnstone/DE/183/94 | H3N1 | 1994 | USA | 1.12 ± 0.39 |
A/Shorebird/DE/39/95 | H3N1 | 1995 | USA | 3.23 ± 1.33 |
A/Shorebird/DE/288/95 | H3N1 | 1995 | USA | 0.92 ± 0.33 |
A/Shorebird/DE/24/96 | H11N1 | 1996 | USA | 35.25 ± 3.06 |
A/Ruddy Turnstone/DE/125/96 | H12N1 | 1996 | USA | 45.82 ± 2.44 |
A/Shorebird/DE/111/97 | H2N1 | 1997 | USA | 39.00 ± 2.84 |
A/Shorebird/DE/138/97 | H2N1 | 1997 | USA | 2.68 ± 0.21 |
A/Shorebird/DE/182/97 | H2N1 | 1997 | USA | 154.43 ± 38.53 |
A/Shorebird/DE/24/98 | H2N1 | 1998 | USA | 111.07 ± 18.61 |
A/Shorebird/DE/95/2003 | H9N1 | 2003 | USA | 67.00 ± 11.16 |
A/Shorebird/DE/68/2003 | H9N1 | 2003 | USA | 52.85 ± 13.95 |
A/Laughing Gull/DE/5/2003 | H9N1 | 2003 | USA | 65.80 ± 17.88 |
A/Shorebird/DE/65/2003 | H9N1 | 2003 | USA | 5.63 ± 2.63 |
A/Ruddy Turnstone/NJ/AI07-69/2007 | H5N1 | 2007 | USA | 5.79 ± 1.36 |
A/Ruddy Turnstone/NJ/AI07-72/2007 | H9N1 | 2007 | USA | 6.46 ± 1.57 |
A/Ruddy Turnstone/NJ/AI07-283/2007 | H9N1 | 2007 | USA | 5.59 ± 1.61 |
A/Ruddy Turnstone/NJ/AI07-296/2007 | H6N1 | 2007 | USA | 7.36 ± 3.96 |
A/Ruddy Turnstone/NJ/AI07-699/2007 | H5N1 | 2007 | USA | 4.60 ± 1.44 |
A/Ruddy Turnstone/NJ/AI07-839/2007 | H12N1 | 2007 | USA | 6.60 ± 2.22 |
Swinec | ||||
A/Swine/NC/38448-1/2005 | H1N1 | 2005 | USA | 2.11 ± 0.91 |
A/Swine/KS/029170/2007 | H1N1 | 2007 | USA | 0.33 ± 0.12 |
A/Swine/OK/038826/2007 | H1N1 | 2007 | USA | 1.82 ± 0.42 |
A/Swine/NE/047330/2007 | H1N1 | 2007 | USA | 0.90 ± 0.49 |
A/Swine/OH/004880/2008 | H1N1 | 2008 | USA | 3.31 ± 1.52 |
A/Swine/NC/007270/2008 | H1N1 | 2008 | USA | 1.12 ± 0.65 |
A/Swine/KY/012454/2008 | H1N1 | 2008 | USA | 1.44 ± 0.18 |
A/Swine/MN/016245/2008 | H1N1 | 2008 | USA | 0.66 ± 0.43 |
A/Swine/WI/018247-2/2008 | H1N1 | 2008 | USA | 1.27 ± 0.48 |
A/Swine/IL/020968/2008 | H1N1 | 2008 | USA | 1.90 ± 0.66 |
A/Swine/MO/044329/2008 | H1N1 | 2008 | USA | 0.65 ± 0.25 |
A/Swine/MN/055403-3/2008 | H1N1 | 2008 | USA | 0.79 ± 0.27 |
A/Swine/IA/056944/2008 | H1N1 | 2008 | USA | 1.77 ± 0.79 |
A/Swine/IL/060530/2008 | H1N1 | 2008 | USA | 0.92 ± 0.12 |
A/Swine/IA/003479/2009 | H1N1 | 2009 | USA | 2.56 ± 1.50 |
Influenza viruses obtained from avian sources were all from apparently healthy wild birds and were isolated from fecal samples or from tracheal/oropharyngeal or cloacal swabs. Stock viruses of avian isolates were made by passaging in 10-day-old embryonated chicken eggs. Two-letter abbreviations in virus names correspond to standard postal abbreviations for states.
The NA inhibition assay used MUNANA as substrate (final concentration, 100 μM). Values are the means of at least three independent determinations.
Influenza viruses from pigs were from animals with respiratory disease and were isolated from bronchial swabs, nasal swabs, or lung tissues.