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Development of vaccine-induced antibody responses. The quantity of anti-MARV GP IgG in plasma samples from vaccinated cynomolgus macaques was determined by ELISA as described in Materials and Methods. Results are shown for samples obtained at days 0, 28, 56, 122, and 163 and 0, 28, 56, 122, 163, and 177 for the DNA/rAd5 (A) and DNA-only (B) groups, respectively. Data for day 0 and 21 samples from rAd5-only-vaccinated NHP are presented in panel C. Arrows show times of vaccinations.
