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. 2010 Jul 28;84(19):10329–10343. doi: 10.1128/JVI.00923-10

FIG. 1.

FIG. 1.

miR200 family. (A) Schematic diagram of the promoter region of the EBV BZLF1 gene indicating known cis-acting elements and their trans-acting factors. (B) Schematic diagram of the miRBase-predicted locations of hsa-miR200a, hsa-miR200b, and hsa-miR429 on chromosome 1 and hsa-miR200c and hsa-miR141 on chromosome 12. (C) Sequences of miRNA200 family members. The miRBase program (50, 51) was used to generate the sequences of the five human miRNA-200 family members, hsa-miR200a, hsa-miR200b, hsa-miR200c, hsa-miR429, and hsa-miR141. Seed sequences for each miRNA are highlighted in the boxed area; polymorphisms in the sequences are underlined. (D) TargetScan (50, 51)-predicted binding sites for miR200 family members in the 3′-UTR regions of ZEB2 and ZEB1 mRNAs. Binding sites for hsa-miR200b, hsa-miR200c, and hsa-miR429 are indicated by black rectangles; binding sites for hsa-miR200a and hsa-miR141 are indicated by gray rectangles.