FIG. 1.
(A) Amino acid sequence alignments of B-WT and AE-WT and NFV-resistant mutants. Residue positions that differ between clade B and AE are indicated in red. NFV resistance mutations are indicated in blue. (B) Ribbon diagram superposition of DRVAE-WT (blue) and DRVAE-N88S (gray). (C) Double-difference plot comparing DRVAE-WT and DRVAE-N88S. (D) Ribbon diagram superposition of clade DRVAE-WT (magenta) and clade DRVB-WT (gray). (E) Double-difference plot comparing DRVAE-WT and DRVB-WT. The color contours in the double-difference plots indicate distance differences of <1.0 Å (black), 1.0 to 0.5 Å (green), 0.5 to 1.0 Å (blue), and >1.0 Å (red).