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(A) Ribbon diagram superposition of DRVAE-WT (blue) and DRVB-WT (gray). The red box indicates the region of the protease molecule highlighted in panels B to D. (B) Structural rearrangement of the flap hinge and core regions between DRVAE-WT (blue) and DRVB-WT (gray). (C) Flap hinge and core regions of DRVAE-WT. (D) Flap hinge and core regions of DRVB-WT protease. Hydrogen bond interactions are indicated by red dashed lines.
