TABLE 1.

Crystallographic statistics

Parametera	Result for indicated variant
	DRVB-WTb	DRVB-D30N/N88D	DRVAE-WT	DRVAE-N88S
Inhibitor	DRV	DRV	DRV	DRV
Resolution (Å)	1.2	2.15	1.96	1.76
Space group	P 21 21 21	P 21 21 21	P 61	P 61
Z	4	4	6	6
Cell dimensions (Å)
a	54.9	50.9	62.2	61.9
b	57.8	57.7
c	62.0	61.6	82.7	82.1
Total no. of reflections	302,022	108,838	89,284	79,445
No. of unique reflections	55,056	10,326	12,493	17,277
Rsymm (%)	3.8	6.7	5.5	4.6
Completeness (%)	95.5	99.6	93.9	97.4
I/σI	25.0	9.6	11.2	19.6
Rwork (%)	14.1	18.1	20.0	19.6
Rfree (%)	17.9	23.6	25.9	23.9
RMSD
Bond length (Å)	0.004	0.009	0.009	0.007
Bond angle	1.5	1.9	1.5	1.7
PDB code	1T3R	3LZV	3LZS	3LZU

^aZ, number of molecules in the unit cell; RMSD, root mean square deviation; R_symm = Σ_hkl|I_hkl − <I_hkl>|/Σ_hklI_hkl; I/σ^I, signal-to-noise ratio; R_work = Σ|F_obs − F_cal|/ΣF_obs; R_free = Σ_test(|F_obs| − F_cal|)²/Σ_test|F_obs|².

^bSee King et al.(21) and Surleraux et al. (40).