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. 2010 Jul 9;285(37):28472–28480. doi: 10.1074/jbc.M110.133520

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© 2010 by The American Society for Biochemistry and Molecular Biology, Inc.

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FIGURE 3. — Curcumin treatment alters APP metabolism in H4-APP751 cells and CHO-APP751 cells in a dose-dependent manner. Various cell models were treated with different concentrations of curcumin for 24 h and collected for Western blotting analysis. Cell lysates were probed with the APP8717 antibody to reveal APP. β-Actin was used as the loading control. A and B, the effects of curcumin treatment on H4-APP751 cells. Curcumin treatment had a trend to increase the level of mature APP, significantly increased the levels of immature APP and total APP, and markedly decreased the ratio of APPma/APPim. C and D, the effects of curcumin on CHO-APP751 cells. Curcumin significantly increased the levels of mature APP, immature APP, and total APP and had a trend to decrease the ratio of APPma:APPim with increasing concentration (n = 3 for each treatment group). Mean ± S.E.; *, p < 0.05; **, p < 0.01.