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miR-26a pathway in the initiation of HASMC hypertrophy. Up-regulation of miR-26a by stretching of HASMCs or enforced expression of mir-26a suppresses GSK-3β protein expression that triggers global cellular protein synthesis. As a result, smooth muscle hypertrophic marker proteins (α-actin, SM22, and MHC) are up-regulated, which, in turn, initiates hypertrophy.
