FIGURE 1.

Domain structure and binding partners of talin. Schematic diagram of the talin molecule indicating the regions involved in binding to various ligands. The talin head (residues 1–400) contains a FERM domain (comprising F1, F2, and F3 subdomains) preceded by a domain region referred to as F0 (16). The rod domain contains 62 predicted α-helices (ovals) organized into a series of amphipathic helical bundles. Domain boundaries based on structural determination are indicated by solid lines. Dashed lines indicate boundaries that are tentative. The ∼11 VBS are shown in red. The last α-helix (blue) contains the dimerization domain (DD) (27).