Table V.
Association between cutaneous melanoma risk and VDR TaqI, BsmI, and VDR FokI genotypes, stratified by risk factors, in non-Hispanic whites, Texas, 1994–2006
| Variable | FokI Ff+ff (no. cases/no. controls) | FokI FF (no. cases/no. controls) | ||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| TaqI | BsmI | TaqI | BsmI | |||||||||||||||||
| TT | Tt+tt | Odds ratio‡ | CI | p§ | bb | Bb+BB | Odds ratio‡ | CI | p§ | TT | Tt+tt | Odds ratio‡ | CI | p§ | bb | Bb+BB | Odds ratio‡ | CI | p§ | |
| Age (years) | 0.03 | 0.01 | 0.80 | 0.71 | ||||||||||||||||
| ≤50 | 39/55 | 75/78 | 1.35 | 0.80, 2.27 | 35/51 | 79/82 | 1.40 | 0.82–2.38 | 87/56 | 117/121 | 0.62 | 0.41, 0.95 | 85/58 | 119/119 | 0.68 | 0.45, 1.04 | ||||
| >50 | 80/62 | 93/149 | 0.50 | 0.33, 0.76 | 71/60 | 102/151 | 0.58 | 0.38–0.89 | 124/96 | 190/224 | 0.66 | 0.48, 1.92 | 114/96 | 200/224 | 0.76 | 0.54, 1.05 | ||||
| Sex | 0.18 | 0.17 | 0.19 | 0.05 | ||||||||||||||||
| Male | 78/73 | 104/157 | 0.62 | 0.41, 0.93 | 69/68 | 113/162 | 0.69 | 0.46–1.04 | 132/108 | 200/227 | 0.74 | 0.54, 1.02 | 121/111 | 211/224 | 0.89 | 0.64, 1.22 | ||||
| Female | 41/44 | 64/70 | 1.00 | 0.58, 1.72 | 37/43 | 68/71 | 1.11 | 0.64–1.93 | 79/44 | 107/118 | 0.50 | 0.32, 0.79 | 78/43 | 108/119 | 0.50 | 0.32, 0.78 | ||||
| Skin color | 0.07 | 0.65 | 0.70 | |||||||||||||||||
| Black or brown | 55/43 | 72/86 | 0.66 | 0.39, 1.09 | 54/38 | 68/71 | 0.55 | 0.32–0.92 | 82/61 | 119/157 | 0.55 | 0.36, 0.83 | 74/64 | 127/154 | 0.70 | 0.47, 1.06 | ||||
| Fair | 55/53 | 81/109 | 0.74 | 0.45, 1.19 | 44/54 | 73–91 | 1.08 | 0.66–1.77 | 104/62 | 164/150 | 0.65 | 0.44, 0.96 | 104/61 | 164/151 | 0.65 | 0.44, 0.96 | ||||
| Hair color | 0.45 | 0.81 | 0.05 | 0.03 | ||||||||||||||||
| Black or brown | 70/77 | 105/55 | 0.76 | 0.51, 1.15 | 64/73 | 111/159 | 0.81 | 0.53, 1.22 | 124/92 | 184/255 | 0.54 | 0.39, 0.75 | 119/93 | 189/254 | 0.58 | 0.42, 0.81 | ||||
| Blond(e) or red | 40/18 | 48/39 | 0.57 | 0.28, 1.14 | 34/18 | 54/39 | 0.73 | 0.36, 1.50 | 62/31 | 99/49 | 1.04 | 0.60, 1.82 | 59/32 | 102/48 | 1.20 | 0.69, 2.09 | ||||
| Eye color | 0.12 | 0.26 | 0.38 | 0.44 | ||||||||||||||||
| Other | 63/77 | 93/144 | 0.79 | 0.52, 1.21 | 57/73 | 99/148 | 0.86 | 0.56, 1.33 | 63/46 | 93/60 | 0.55 | 0.39, 0.79 | 106/90 | 162/233 | 0.62 | 0.44, 0.87 | ||||
| Blue | 46/17 | 60/51 | 0.42 | 0.21, 0.82 | 40/17 | 66/51 | 0.53 | 0.27, 1.04 | 77/17 | 144/51 | 0.73 | 0.45, 1.20 | 72/35 | 129/81 | 0.79 | 0.48, 1.29 | ||||
| Tanning ability | 0.44 | 0.05 | 0.74 | 0.83 | ||||||||||||||||
| Good (high) | 30/31 | 41/75 | 0.55 | 0.29, 1.05 | 31/28 | 40/78 | 0.43 | 0.22, 0.83 | 40/48 | 62/113 | 0.67 | 0.40, 1.14 | 40/50 | 62/111 | 0.71 | 0.42, 1.20 | ||||
| Poor (low) | 80/65 | 112/119 | 0.77 | 0.51, 1.17 | 67/64 | 125/120 | 1.00 | 0.65, 1.53 | 146/75 | 221/193 | 0.60 | 0.42, 0.84 | 138/75 | 229/193 | 0.66 | 0.47, 0.92 | ||||
| Lifetime sunburn with blistering | 0.83 | 0.92 | 0.42 | 0.93 | ||||||||||||||||
| None | 34/38 | 49/84 | 0.63 | 0.35, 1.14 | 31/38 | 52/84 | 0.73 | 0.40, 1.32 | 38/50 | 70/124 | 0.75 | 0.45, 1.25 | 39/48 | 69/126 | 0.68 | 0.40, 1.14 | ||||
| ≥1 | 74/156 | 105/111 | 0.71 | 0.45, 1.10 | 65/52 | 114/115 | 0.79 | 0.50, 1.23 | 146/173 | 208/181 | 0.58 | 0.41, 0.82 | 137/77 | 217/177 | 0.70 | 0.49, 0.98 | ||||
| Freckling in the sun as a child | 0.45 | 0.71 | 0.10 | 0.23 | ||||||||||||||||
| No | 62/56 | 71/109 | 0.57 | 0.35, 0.91 | 54/54 | 79/111 | 0.69 | 0.42, 1.11 | 83/83 | 127/173 | 0.74 | 0.50, 1.08 | 80/82 | 130/174 | 0.77 | 0.53, 1.13 | ||||
| Yes | 48/39 | 81/85 | 0.77 | 0.45, 1.30 | 44/37 | 85/87 | 0.81 | 0.47, 1.38 | 102/40 | 154/133 | 0.46 | 0.30, 0.71 | 98/43 | 158/130 | 0.55 | 0.36, 0.84 | ||||
| Moles | 0.94 | 0.67 | 0.35 | 0.65 | ||||||||||||||||
| No | 25/30 | 43/71 | 0.73 | 0.38, 1.41 | 21/30 | 47/71 | 0.98 | 0.50, 1.92 | 40/47 | 67/141 | 0.57 | 0.34, 0.95 | 39/53 | 68/135 | 0.70 | 0.42, 1.16 | ||||
| Yes | 94/87 | 125/156 | 0.76 | 0.52, 1.11 | 85/81 | 134/162 | 0.81 | 0.55, 1.19 | 171/105 | 240/204 | 0.74 | 0.54, 1.01 | 160/101 | 251/208 | 0.79 | 0.57, 1.07 | ||||
| Dysplastic nevi | 0.98 | 0.51 | 0.28 | 0.24 | ||||||||||||||||
| No | 113/115 | 155/227 | 0.70 | 0.50, 0.97 | 100/110 | 168/232 | 0.80 | 0.57, 1.12 | 190/151 | 282/339 | 0.66 | 0.51, 0.86 | 178/153 | 294/337 | 0.75 | 0.57, 0.98 | ||||
| Yes | 6/2 | 13/0 | NC | 6/1 | 13/1 | 0.48 | 0.01, 40.2 | 21/1 | 25/6 | 0.07 | 0.01, 0.99 | 21/1 | 25/6 | 0.07 | 0.01, 0.98 | |||||
| First-degree relatives with any cancer | 0.36 | 0.94 | 0.49 | 0.63 | ||||||||||||||||
| No | 43/67 | 67/122 | 0.86 | 0.53, 1.40 | 42/62 | 68/127 | 0.79 | 0.48, 1.29 | 104/77 | 129/165 | 0.58 | 0.40, 0.85 | 96/77 | 137/165 | 0.68 | 0.46, 0.99 | ||||
| Yes | 76/50 | 101/105 | 0.64 | 0.41, 1.00 | 64/49 | 113/106 | 0.83 | 0.52, 1.31 | 107/75 | 178/180 | 0.70 | 0.49, 1.00 | 103/77 | 182/178 | 0.77 | 0.53, 1.10 | ||||
*
The numbers of subjects in some of the strata were less than the total number of subjects included in this study because some subjects did not provide the information.
†
CI, confidence interval.
‡
Odds ratios were adjusted for age and sex in a logistic regression model.
§
p values for interaction were obtained from logistic regression models after adjustment for age, sex, and the main effects of the interactive variables.