Table VI.
Multivariate logistic regression analysis of associations between VDR TaqI, BsmI, and FokI genotype frequencies and cutaneous melanoma risk in non-Hispanic whites, Texas, 1994–2006
| Variable | β | Wald χ2− | p | Odds ratio | 95 percent confidence interval |
|---|---|---|---|---|---|
| Model 1 (805 cases and 841 controls) | |||||
| Age (years) | −0.007 | 2.59 | 0.11 | 0.99 | 0.99, 1.00 |
| Sex (male vs. female) | 0.13 | 1.51 | 0.22 | 1.14 | 0.93, 1.40 |
| VDR BsmI (Bb+BB vs. bb) | 0.21 | 1.11 | 0.29 | 1.23 | 0.84, 1.82 |
| VDR FokI (Ff+ff vs. FF) | 0.24 | 5.39 | 0.02 | 1.27 | 1.04, 1.55 |
| VDR TaqI (Tt+tt vs. TT) | −0.57 | 8.20 | 0.004 | 0.57 | 0.39, 0.84 |
| Model 2 (712 cases and 707 controls) * | |||||
| Age (years) | −0.01 | 0.11 | 0.74 | 1.00 | 0.99, 1.01 |
| Sex (male vs. female) | 0.08 | 0.42 | 0.52 | 1.08 | 0.88, 1.37 |
| Eye color (other vs. blue) | 0.58 | 21.7 | <0.001 | 1.79 | 1.40, 2.29 |
| Hair color (blond[e] or red vs. black or brown) | 0.46 | 11.3 | <0.001 | 1.58 | 1.21, 2.07 |
| Lifetime sunburns with blistering (≥1 vs. 0) | 0.45 | 12.9 | <0.001 | 1.56 | 1.23, 1.99 |
| Tanning ability after prolonged sun exposure (moderate or poor vs. good) | 0.37 | 8.55 | 0.003 | 1.45 | 1.13, 1.86 |
| Moles (yes vs. no) | 0.65 | 27.9 | <0.001 | 1.92 | 1.51, 2.44 |
| Pigmented nevi (yes vs. no) | 1.70 | 20.9 | <0.001 | 5.46 | 2.64, 11.3 |
| Family history of skin cancer (yes vs. no) | 0.27 | 5.25 | 0.02 | 1.31 | 1.04, 1.65 |
| VDR FokI (Ff+ff vs. FF) | 0.15 | 1.55 | 0.21 | 1.16 | 0.92, 1.46 |
| VDR TaqI (Tt+tt vs. TT) | −0.38 | 10.3 | 0.001 | 0.68 | 0.54, 0.86 |
*
The numbers of subjects included in this model were less than the total number of subjects included in this study because this model only included subjects who provided complete information in their screening questionnaires.