Table 1.
Genotype and allele frequencies of the TP53 Arg72Pro, p73 G4C14>A4T14 and p21 Ser31Arg polymorphisms and their associations with risk of CM
| Genotype | Patients (n = 805) | Controls (n = 838)1 | p value2 | Crude OR (95% CI) | Adjusted OR (95% CI)3 | Adjusted OR (95% CI)4 | ||
|---|---|---|---|---|---|---|---|---|
| N | % | N | % | |||||
| TP53 Arg72Pro | 0.029 | |||||||
| Pro/Pro5 | 40 | 5.0 | 56 | 6.7 | 1.00 | 1.00 | 1.00 | |
| Arg/Pro | 300 | 37.2 | 350 | 41.8 | 1.20 (0.77–1.85) | 1.20 (0.78–1.86) | 1.28 (0.73–2.23) | |
| Arg/Arg | 465 | 57.8 | 432 | 51.5 | 1.51 (0.98–2.31) | 1.50 (0.98–2.30) | 1.50 (0.87–2.60) | |
| Arg/Pro+Pro/Pro 6 | 340 | 42.2 | 406 | 48.5 | 1.00 | 1.00 | 1.00 | |
| Arg/Arg | 465 | 57.8 | 432 | 51.5 | 1.28 (1.05–1.55) | 1.28 (1.05–1.55) | 1.21 (0.95–1.56) | |
| Pro allele frequency | 0.236 | 0.276 | 0.010 | |||||
| p73 G4C14>A4T14 | 0.377 | |||||||
| GC/GC 5 | 468 | 58.1 | 497 | 59.3 | 1.00 | 1.00 | 1.00 | |
| GC/AT | 287 | 35.7 | 302 | 36.0 | 1.01 (0.82–1.24) | 1.01 (0.82–1.24) | 1.01 (0.84–1.41) | |
| AT/AT | 50 | 6.2 | 39 | 4.7 | 1.37 (0.88–2.12) | 1.37 (0.88–2.12) | 1.33 (0.76–2.33) | |
| GC/AT+GC/GC5 | 755 | 93.8 | 799 | 95.4 | 0.163 | 1.00 | 1.00 | 1.00 |
| AT/AT | 50 | 6.2 | 39 | 4.7 | 1.36 (0.89–2.10) | 1.36 (0.89–2.10) | 1.29 (0.75-2.24) | |
| AT allele frequency | 0.24 | 0.227 | 0.401 | |||||
| p21 Ser31Arg | 0.815 | |||||||
| Ser/Ser 5 | 695 | 86.3 | 731 | 87.2 | 1.00 | 1.00 | 1.00 | |
| Ser/Arg | 106 | 13.2 | 104 | 12.4 | 1.07 (0.80–1.43) | 1.06 (0.79–1.41) | 1.29 (0.88–1.90) | |
| Arg/Arg | 4 | 0.5 | 3 | 0.4 | 1.40 (0.31–6.28) | 1.48 (0.33–6.65) | 1.33 (0.18–9.82) | |
| Ser/Arg+Arg/Arg | 110 | 13.7 | 107 | 12.8 | 0.592 | 1.08 (0.81–1.44) | 1.07 (0.80–1.42) | 1.30 (0.88–1.89) |
| Arg allele frequency | 0.071 | 0.066 | 0.618 | |||||
The observed genotype frequency among the control subjects was in agreement with the Hardy-Weinberg equilibrium (Chi-square test = 1.763, p = 0.184 for TP53 Arg72Pro; χ2 = 0.646, p = 0.422 for p73 G4C14>A4T14; and χ2 = 0.118, p = 0.731 for p21 Ser31Arg).
Two-sided χ2 test for either genotype distribution or allele frequency.
ORs were adjusted for age and sex.
ORs were adjusted for age, sex, skin color eye color, hair color, tanning ability, life time number of sunburns with blistering, freckling in the sun as a child, presence of moles or dyplastic nevi and family history of cancer (cases=700 and controls=513 due to missing data).
Individual comparison reference.
Combine comparison reference.