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. Author manuscript; available in PMC: 2011 Jan 1.
Published in final edited form as: Biopolymers. 2010;94(4):521–529. doi: 10.1002/bip.21387

Figure 5.

Figure 5

Crystal structure of the D-enantiomer of backbone engineered HIV-1 PR prepared by total chemical synthesis complexed to D-MVT101 inhibitor. (a) Cocrystals were obtained from 50% ammonium sulfate, pH 5.4, in the space group P212121 a = 67.5, b = 92.8, c = 29.4 Å. There were two monomers of protein and one inhibitor in the crystallographic asymmetric unit. (b) Stereo view of Cα tracing of D HIV-1 PR. Bound D MVT-101 inhibitor is shown as green sticks. Coordinates were deposited to HIV Structural Database;48 accession code: NCI2009.