Table 3.
Response category | Criteria |
---|---|
Complete metabolic response | Normalization of all lesions (target and nontarget) to SUL less than mean liver SUL and equal to normal surrounding tissue SUL |
Verification with follow-up study in 1 month if anatomic criteria indicate disease progression | |
Partial metabolic response | > 30% decrease in SUL peak; minimum 0.8 unit decrease* |
Verification with follow-up study if anatomic criteria indicate disease progression | |
Progressive metabolic disease | > 30% increase in SUL peak; minimum 0.8 unit increase in SUL peak* |
> 75% increase in TLG of the 5 most active lesions | |
Visible increase in extent of FDG uptake | |
New lesions | |
Verification with follow-up study if anatomic criteria indicate complete or partial response | |
Stable metabolic disease | Does not meet other criteria |
*Primary outcome determination is measured on the single most active lesion on each scan (not necessarily the same lesion). Secondary outcome determination is the summed activity of up to 5 most intense lesions (no more than 2 lesions per organ).
Abbreviations: SUL, standardized uptake value using lean body mass; TLG, total lesion glycolysis.
Table modified from Wahl et al. 27.