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. Author manuscript; available in PMC: 2010 Sep 13.
Published in final edited form as: Nature. 2010 Feb 21;464(7287):409–412. doi: 10.1038/nature08801

Figure 2. Deletion of the CAD risk interval affects expression of neighboring genes Cdkn2a and Cdkn2b.

Figure 2

a) Expression levels of Cdkn2a (INK splice variant) and Cdkn2b are significantly reduced in heart tissue of chr4Δ70kb/Δ70kb mice. In contrast, expression of the neighboring genes Mtap and Dmrta1 is not significantly altered. b) Overview of locus with locations of genes. Error bars are standard error of the mean; asterisks indicate P ≤ 0.005 (t-test, one-tailed).