Table II. Summary of ligand specificity versus function of proteins identified bound to ERE-ER.
| Category | No. proteins found | Ligand specificitya |
|---|---|---|
| Cell cycle regulation | 7 | E2 |
| Cell structure, adhesion, migration | 12 | 4-OHT |
| Cytokinesis, vesicle trafficking | 4 | No specificity |
| Histone deacetylation | 2 | 4-OHT |
| Nucleic acid stability | 14 | No specificity |
| Nucleosome structure | 4 | No specificity |
| Protein degradation | 2 | E2/ICIb |
| Protein folding | 7 | E2/4-OHT |
| Transcriptional regulation | 20 | E2 |
| Translation | 31 | E2 |
| Other | 7 | No specificity |
a Cutoff of 2-fold enrichment between ligand treatments used.
b ICI-182,780.