Table III. Antibody array data showing differentially expressed proteins induced by NPM-ALK.
W/F, wild type/FFF mutant; MAP, mitogen-activated protein.
| Symbol | Protein name | Ratio (W/F) | Symbol | Protein name | Ratio (W/F) |
|---|---|---|---|---|---|
| Peptidase | |||||
| ADAM17 | Disintegrin and metalloproteinase domain-containing protein 17 | 2.08 | Caspase13 | Caspase 13, apoptosis-related cysteine peptidase | 2.17 |
| CTSD | Cathepsin D | 2.17 | |||
| Cytokine | |||||
| TNFSF13 | Tumor necrosis factor (ligand) superfamily, member 13 (APRIL) | 2.20 | TNF | Tumor necrosis factor (TNF superfamily, member 2) | 13.75 |
| TNFSF10 | Tumor necrosis factor (ligand) superfamily, member 10 (TRAIL) | 3.00 | |||
| Enzyme | |||||
| OGT | O-Linked N-acetylglucosamine (GlcNAc) transferase | 2.35 | RRM2B | Ribonucleotide reductase M2 B (TP53-inducible) | 2.73 |
| DNASE2A | Deoxyribonuclease II, lysosomal | 2.58 | |||
| Kinase | |||||
| CSNK2B | Casein kinase 2, β polypeptide | 2.28 | MAPK1 | Mitogen-activated protein kinase 1 (ERK2) | 2.12 |
| RIPK2 | Receptor-interacting serine-threonine kinase 2 | 12.49 | MAP2K3 | Mitogen-activated protein kinase kinase 3 | 21.56 |
| DAPK3 | Death-associated protein kinase 3 | 3.53 | STK17A | Serine/threonine kinase 17a | 2.36 |
| CDK3 | Cyclin-dependent kinase 3 | 2.05 | PRKCB | Protein kinase C, β | 2.51 |
| Transcription regulator | |||||
| HDAC7 | Histone deacetylase 7 | 3.37 | JUN | Jun oncogene | 2.30 |
| MTA2 | Metastasis-associated 1 family, member 2 | 2.26 | TSG101 | Tumor susceptibility gene 101 | 2.76 |
| Sirt1 | Sirtuin (silent mating type information regulation 2 homolog) 1 | 2.26 | RYBP | RING1- and YY1-binding protein | 2.35 |
| c-Myc | Myelocytomatosis viral oncogen homolog | 2.18 | RND3 | Rho family GTPase 3 | 2.40 |
| Transmembrane receptor | |||||
| TNFRSF10C | Tumor necrosis factor receptor superfamily, member 10c (DcR1) | 2.40 | TNFRSF10D | Tumor necrosis factor receptor superfamily, member 10d (DcR2) | 2.34 |
| TNFRSF6B | Tumor necrosis factor receptor superfamily, member 6b (DcR3) | 2.57 | TNFRSF25 | Tumor necrosis receptor superfamily, member 25 (DR3) | 2.61 |
| TNFRSF10B | Tumor necrosis factor receptor superfamily, member 10b (DR5) | 2.39 | TNFRSF21 | Tumor necrosis factor superfamily member 21 (DR6) | 3.10 |
| Growth factor | |||||
| TGFB1 | Transforming growth factor, β1 | 2.23 | |||
| Transporter | |||||
| SYT1 | Synaptotagmin I | 2.03 | |||
| Others | |||||
| HSPA9 | Heat shock 70-kDa protein 9 (mortalin) | 2.45 | H3F3A | H3 histone, family 3A | 3.08 |
| MADD | MAP kinase-activating death domain | 3.11 | MAP1B | Microtubule-associated protein 1B | 2.24 |
| MTBP | Mdm2, transformed 3T3 cell double minute 2, p53-binding protein (mouse)-binding protein, 104 kDa | 2.74 | MYD88 | Myeloid differentiation primary response gene (88) | 2.02 |
| Ppp1r9a | Protein phosphatase 1, regulatory subunit 9A | 3.20 | PPP1R9B | Protein phosphatase 1, regulatory subunit 9b | 2.64 |
| PERP | PERP, TP53 apoptosis effector | 3.51 | BBC3 | BCL2 binding component 3 | 3.01 |
| CRADD | CASP2 and RIPK1 domain-containing adaptor with death domain | 15.29 | MAPT | Microtubule-associated protein tau | 5.35 |
| IFRD1 | Interferon-related developmental regulator 1 | 2.01 | CCND1 | Cyclin D1 | 2.49 |
| APAF1 | Apoptotic peptidase activating factor 1 | 2.27 | BID | BH3-interacting domain death agonist | 2.06 |
| BCL2L1 | BCL2-like 1 | 3.29 |