Fig. 6.

FA signaling network. Integrated network of enriching phosphoproteins, signaling proteins known to regulate responses to FAs, and regulatory proteins. Proteins are indicated by nodes, and protein-protein interactions are shown by edges between the nodes. Green nodes indicate enrichment in oleic acid, red nodes indicate enrichment in glucose, blue nodes indicate enrichment of different sites in glucose and oleic acid, and white nodes indicate no information on phosphorylation status. The node border indicates the role of the protein as a positive (red), negative (green), or neutral (gray) effector of expression of FA-responsive loci. Diamond-shaped nodes indicate kinases, parallelogram-shaped nodes indicate phosphatases, octagonal nodes indicate regulators, circular nodes indicate transcription factors, and rounded rectangular nodes indicate phosphorylation substrates. The network is provided as a Cytoscape file (supplemental FA_Net_Saleem_MCP.cys) to facilitate interactive viewing.