Table 1.

Central residues in the closed and two open conformations of Hsp70 NBD.

PDB id	L(Å)	Binding NEF	conformation	Central residues(*)
				shared by all	Specific to examined structures
1hpm	14.06	None	closed	Lys71 Arg72 Glu175 His227	Tyr15 Tyr41 Arg261 Arg272
1hx1	14.67	BAG	open		Ala60 Arg261 Arg342 Asp366
3c7n	15.26	Sse1	open		Leu73 Asp232 Lys271 Arg342

(*) fully conserved residues are written in boldface (see Fig. 4a). Note that Leu73 and Asp232 are also highly conserved.