Mean lesion volumes obtained with variations of the bias regularization parameter in the unmasked condition (n=49). Warping regularization was held at medium for all conditions. Low bias = 0.00001; medium bias = 0.0001; high bias = 0.001.
*Smoothed, precisely masked lesion volume (127,458 mm3, S.E. = 14,232) significantly larger than lesion volumes obtained in all unmasked conditions (low bias = 121,079 mm3, S.E. = 13,519; medium bias = 121,602 mm3, S.E. = 13,646; and high bias = 122,211 mm3, S.E. = 13,731).